TY - JOUR
T1 - Brain infections that mimic malignancy
AU - Godkhindi, Vishwapriya Mahadev
AU - Monappa, Vidya
AU - Kairanna, Nikitha Valerina
AU - Sharma, Swati
AU - Vasudevan, Geetha
AU - Hebbar, Karthikeya D.
N1 - Publisher Copyright:
© 2022
PY - 2022/10
Y1 - 2022/10
N2 - There exists a wide spectrum of non-neoplastic conditions which can mimic a brain tumor, both clinically and radiologically. Central nervous system (CNS) infections are the commonest conditions in this group. CNS infections presenting as space-occupying lesions (SOLs) are not uncommon, especially in developing countries with large populations in the low socio-economic groups. The infective organisms gain entry into the CNS via hematogenous dissemination, seed the parenchyma, cause tissue destruction, expansion and a host tissue response, which all contribute to the formation of SOLs, akin to neoplasms. Enhancing lesions with perilesional edema and mass effect on neuroimaging is a characteristic feature of neoplasms. Similar findings have been observed in non-neoplastic conditions, especially CNS infections. Unless there is a suspicion of infection, these lesions will be missed and treatment delayed with resultant morbidity and mortality. This review discusses the common infectious lesions that mimic CNS malignancy.
AB - There exists a wide spectrum of non-neoplastic conditions which can mimic a brain tumor, both clinically and radiologically. Central nervous system (CNS) infections are the commonest conditions in this group. CNS infections presenting as space-occupying lesions (SOLs) are not uncommon, especially in developing countries with large populations in the low socio-economic groups. The infective organisms gain entry into the CNS via hematogenous dissemination, seed the parenchyma, cause tissue destruction, expansion and a host tissue response, which all contribute to the formation of SOLs, akin to neoplasms. Enhancing lesions with perilesional edema and mass effect on neuroimaging is a characteristic feature of neoplasms. Similar findings have been observed in non-neoplastic conditions, especially CNS infections. Unless there is a suspicion of infection, these lesions will be missed and treatment delayed with resultant morbidity and mortality. This review discusses the common infectious lesions that mimic CNS malignancy.
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U2 - 10.1016/j.mpdhp.2022.08.009
DO - 10.1016/j.mpdhp.2022.08.009
M3 - Review article
AN - SCOPUS:85139164901
SN - 1756-2317
VL - 28
SP - 456
EP - 466
JO - Current Diagnostic Pathology
JF - Current Diagnostic Pathology
IS - 10
ER -