TY - JOUR
T1 - Brief review on repurposed drugs and vaccines for possible treatment of COVID-19
AU - De, Priyasha
AU - Chakraborty, Ishita
AU - Karna, Bhargavi
AU - Mazumder, Nirmal
N1 - Funding Information:
We thank the Department of Science and Technology, India (Project No.: DST/INT//BLG/P-03/2019 ) for funding. The authors thank Dr. K. Satyamoorthy, Director, Manipal School of Life Sciences (MSLS), Manipal Academy of Higher Education (MAHE), for his encouragement and MAHE, Manipal, India for providing the infrastructure and facilities. We thank Dr. K. K. Mahato, HoD, Department of Biophysics, MSLS, MAHE, for the fruitful discussion in preparation for this review article.
Publisher Copyright:
© 2021 Elsevier B.V.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/5/5
Y1 - 2021/5/5
N2 - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of the pandemic coronavirus disease 2019 (Covid-19) has claimed more than a million lives. Various in silico, in vitro, and in vivo studies are being conducted to understand the effect of SARS-CoV-2 on the cellular metabolism of humans and the various drugs and drug-targets that may be used. In this review, we discuss protein-protein interactions (PPIs) between viral and human proteins as well as viral targets like proteases. We try to understand the molecular mechanism of various repurposed antiviral drugs against SARS-CoV-2, their combination therapies, drug dosage regimens, and their adverse effects along with possible alternatives like non-toxic antiviral phytochemicals. Ultimately, randomized controlled trials are needed to identify which of these compounds has the required balance of efficacy and safety. We also focus on the recent advancements in diagnostic methods and vaccine candidates developed around the world to fight against Covid-19.
AB - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of the pandemic coronavirus disease 2019 (Covid-19) has claimed more than a million lives. Various in silico, in vitro, and in vivo studies are being conducted to understand the effect of SARS-CoV-2 on the cellular metabolism of humans and the various drugs and drug-targets that may be used. In this review, we discuss protein-protein interactions (PPIs) between viral and human proteins as well as viral targets like proteases. We try to understand the molecular mechanism of various repurposed antiviral drugs against SARS-CoV-2, their combination therapies, drug dosage regimens, and their adverse effects along with possible alternatives like non-toxic antiviral phytochemicals. Ultimately, randomized controlled trials are needed to identify which of these compounds has the required balance of efficacy and safety. We also focus on the recent advancements in diagnostic methods and vaccine candidates developed around the world to fight against Covid-19.
UR - http://www.scopus.com/inward/record.url?scp=85101857039&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85101857039&partnerID=8YFLogxK
U2 - 10.1016/j.ejphar.2021.173977
DO - 10.1016/j.ejphar.2021.173977
M3 - Review article
AN - SCOPUS:85101857039
SN - 0014-2999
VL - 898
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
M1 - 173977
ER -
