TY - JOUR
T1 - Cadmium chloride induces dose-dependent increases in the frequency of micronuclei in mouse bone marrow
AU - Jagetia, Ganesh Chandra
AU - Adiga, Satish Kumar
PY - 1994/4/1
Y1 - 1994/4/1
N2 - The frequency of micronucleated polychromatic erythrocytes (MPCE) and normochromatic erythrocytes (MNCE) was studied in Swiss albino mice treated with 0, 0,025, 0.05, 0.1, 0.25, 0.5, 1 and 2 mg/kg body weight of cadmium chloride. It was observed that cadmium chloride induce a dose-dependent increase in the frequency of MPCE and MNCE. However, this increase was significant only after treatment with 0.05 mg/kg of CdCl2 (MPCE). The polychromatic and normochromatic erythrocyte ratio (PCE/NCE ratio) declined with the increase in CdCl2 dose and this depletion was dose-dependent. A significant decline was observed only after 0.25 mg/kg CdCl2. The dose-response relationship for all three parameters was linear-quadratic.
AB - The frequency of micronucleated polychromatic erythrocytes (MPCE) and normochromatic erythrocytes (MNCE) was studied in Swiss albino mice treated with 0, 0,025, 0.05, 0.1, 0.25, 0.5, 1 and 2 mg/kg body weight of cadmium chloride. It was observed that cadmium chloride induce a dose-dependent increase in the frequency of MPCE and MNCE. However, this increase was significant only after treatment with 0.05 mg/kg of CdCl2 (MPCE). The polychromatic and normochromatic erythrocyte ratio (PCE/NCE ratio) declined with the increase in CdCl2 dose and this depletion was dose-dependent. A significant decline was observed only after 0.25 mg/kg CdCl2. The dose-response relationship for all three parameters was linear-quadratic.
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U2 - 10.1016/0027-5107(94)90170-8
DO - 10.1016/0027-5107(94)90170-8
M3 - Article
C2 - 7512206
AN - SCOPUS:0028267534
SN - 0027-5107
VL - 306
SP - 85
EP - 90
JO - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
JF - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
IS - 1
ER -