Cadmium chloride induces dose-dependent increases in the frequency of micronuclei in mouse bone marrow

Ganesh Chandra Jagetia; Satish Kumar Adiga

doi:10.1016/0027-5107(94)90170-8

Cadmium chloride induces dose-dependent increases in the frequency of micronuclei in mouse bone marrow

Ganesh Chandra Jagetia^*, Satish Kumar Adiga

^*Corresponding author for this work

Department of Clinical Embryology, Kasturba Medical College, Manipal

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

The frequency of micronucleated polychromatic erythrocytes (MPCE) and normochromatic erythrocytes (MNCE) was studied in Swiss albino mice treated with 0, 0,025, 0.05, 0.1, 0.25, 0.5, 1 and 2 mg/kg body weight of cadmium chloride. It was observed that cadmium chloride induce a dose-dependent increase in the frequency of MPCE and MNCE. However, this increase was significant only after treatment with 0.05 mg/kg of CdCl₂ (MPCE). The polychromatic and normochromatic erythrocyte ratio (PCE/NCE ratio) declined with the increase in CdCl₂ dose and this depletion was dose-dependent. A significant decline was observed only after 0.25 mg/kg CdCl₂. The dose-response relationship for all three parameters was linear-quadratic.

Original language	English
Pages (from-to)	85-90
Number of pages	6
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	306
Issue number	1
DOIs	https://doi.org/10.1016/0027-5107(94)90170-8
Publication status	Published - 01-04-1994

All Science Journal Classification (ASJC) codes

Molecular Biology
Health, Toxicology and Mutagenesis

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10.1016/0027-5107(94)90170-8

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title = "Cadmium chloride induces dose-dependent increases in the frequency of micronuclei in mouse bone marrow",

abstract = "The frequency of micronucleated polychromatic erythrocytes (MPCE) and normochromatic erythrocytes (MNCE) was studied in Swiss albino mice treated with 0, 0,025, 0.05, 0.1, 0.25, 0.5, 1 and 2 mg/kg body weight of cadmium chloride. It was observed that cadmium chloride induce a dose-dependent increase in the frequency of MPCE and MNCE. However, this increase was significant only after treatment with 0.05 mg/kg of CdCl2 (MPCE). The polychromatic and normochromatic erythrocyte ratio (PCE/NCE ratio) declined with the increase in CdCl2 dose and this depletion was dose-dependent. A significant decline was observed only after 0.25 mg/kg CdCl2. The dose-response relationship for all three parameters was linear-quadratic.",

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T1 - Cadmium chloride induces dose-dependent increases in the frequency of micronuclei in mouse bone marrow

AU - Jagetia, Ganesh Chandra

AU - Adiga, Satish Kumar

PY - 1994/4/1

Y1 - 1994/4/1

N2 - The frequency of micronucleated polychromatic erythrocytes (MPCE) and normochromatic erythrocytes (MNCE) was studied in Swiss albino mice treated with 0, 0,025, 0.05, 0.1, 0.25, 0.5, 1 and 2 mg/kg body weight of cadmium chloride. It was observed that cadmium chloride induce a dose-dependent increase in the frequency of MPCE and MNCE. However, this increase was significant only after treatment with 0.05 mg/kg of CdCl2 (MPCE). The polychromatic and normochromatic erythrocyte ratio (PCE/NCE ratio) declined with the increase in CdCl2 dose and this depletion was dose-dependent. A significant decline was observed only after 0.25 mg/kg CdCl2. The dose-response relationship for all three parameters was linear-quadratic.

AB - The frequency of micronucleated polychromatic erythrocytes (MPCE) and normochromatic erythrocytes (MNCE) was studied in Swiss albino mice treated with 0, 0,025, 0.05, 0.1, 0.25, 0.5, 1 and 2 mg/kg body weight of cadmium chloride. It was observed that cadmium chloride induce a dose-dependent increase in the frequency of MPCE and MNCE. However, this increase was significant only after treatment with 0.05 mg/kg of CdCl2 (MPCE). The polychromatic and normochromatic erythrocyte ratio (PCE/NCE ratio) declined with the increase in CdCl2 dose and this depletion was dose-dependent. A significant decline was observed only after 0.25 mg/kg CdCl2. The dose-response relationship for all three parameters was linear-quadratic.

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Cadmium chloride induces dose-dependent increases in the frequency of micronuclei in mouse bone marrow

Abstract

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