Caffeic acid, a dietary polyphenol, as a promising candidate for combination therapy

Swastika Maity, Manas Kinra, Madhavan Nampoothiri, Devinder Arora, K. Sreedhara Ranganath Pai, Jayesh Mudgal

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)


Increased effectiveness and decreasing toxicity are prime objectives in drug research. Overwhelming evidence suggests the use of appropriate combination therapy for the better efficacy of drugs owing to their synergistic profile. Dietary active constituents play a major role in health outcomes. Therefore, it is possible to increase the effectiveness of the drug by combining contemporary medication with active natural/semi-synthetic constituents. One such dietary constituent, caffeic acid (CA), is a by-product of the shikimate pathway in plants and is a polyphenol of hydroxycinnamic acid class. Extensive research on CA has proposed its efficacy against inflammatory, neurodegenerative, oncologic, and metabolic disorders. The synergistic/additive effects of CA in combination with drugs like caffeine, metformin, pioglitazone, and quercetin have been reported in several experimental models and thus the present review is an attempt to consolidate outcomes of this research. Multi-target-based mechanistic studies will facilitate the development of effective combination regimens of CA.

Original languageEnglish
Pages (from-to)1271-1283
Number of pages13
JournalChemical Papers
Issue number3
Publication statusPublished - 03-2022

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Chemistry(all)
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering
  • Materials Chemistry


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