Calixarenes and their Relevance in Anticancer Drug Development

Soumyajeet Paul; Ramaiah Selladurai Jeyaprakash; Aravinda Pai; Hillemane Venkatachalam; Bellur Srinivas Jayashree

doi:10.2174/1573406419666230703114605

Calixarenes and their Relevance in Anticancer Drug Development

Soumyajeet Paul, Ramaiah Selladurai Jeyaprakash, Aravinda Pai, Hillemane Venkatachalam, Bellur Srinivas Jayashree^*

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

5 Citations (Scopus)

Abstract

Calixarenes have always captured the attention of several researchers. They have the ability to entrap multiple molecules and form inclusion complexes with drugs due to their unique structure. Due to this property, they are being widely used in the development of several classes of drugs, most notably anticancer drugs. This review attempted to summarize the potential applications of calixarenes and its derivatives in the development of anticancer drugs, with a focus on the delivery of drug classes such as DNA intercalators, taxanes, DNA alkylators, and topoisomerase inhibitors. Calixarene-based macromolecular chemistry could therefore have a high potential for overcoming the toxicity of cancer chemotherapy and achieving targeted drug delivery.

Original language	English
Pages (from-to)	939-945
Number of pages	7
Journal	Medicinal Chemistry
Volume	19
Issue number	10
DOIs	https://doi.org/10.2174/1573406419666230703114605
Publication status	Published - 2023

All Science Journal Classification (ASJC) codes

Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "Calixarenes have always captured the attention of several researchers. They have the ability to entrap multiple molecules and form inclusion complexes with drugs due to their unique structure. Due to this property, they are being widely used in the development of several classes of drugs, most notably anticancer drugs. This review attempted to summarize the potential applications of calixarenes and its derivatives in the development of anticancer drugs, with a focus on the delivery of drug classes such as DNA intercalators, taxanes, DNA alkylators, and topoisomerase inhibitors. Calixarene-based macromolecular chemistry could therefore have a high potential for overcoming the toxicity of cancer chemotherapy and achieving targeted drug delivery.",

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AU - Paul, Soumyajeet

AU - Jeyaprakash, Ramaiah Selladurai

AU - Pai, Aravinda

AU - Venkatachalam, Hillemane

AU - Jayashree, Bellur Srinivas

PY - 2023

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AB - Calixarenes have always captured the attention of several researchers. They have the ability to entrap multiple molecules and form inclusion complexes with drugs due to their unique structure. Due to this property, they are being widely used in the development of several classes of drugs, most notably anticancer drugs. This review attempted to summarize the potential applications of calixarenes and its derivatives in the development of anticancer drugs, with a focus on the delivery of drug classes such as DNA intercalators, taxanes, DNA alkylators, and topoisomerase inhibitors. Calixarene-based macromolecular chemistry could therefore have a high potential for overcoming the toxicity of cancer chemotherapy and achieving targeted drug delivery.

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Calixarenes and their Relevance in Anticancer Drug Development

Abstract

All Science Journal Classification (ASJC) codes

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