Calixarenes and their Relevance in Anticancer Drug Development

Soumyajeet Paul, Ramaiah Selladurai Jeyaprakash, Aravinda Pai, Hillemane Venkatachalam, Bellur Srinivas Jayashree

Research output: Contribution to journalShort surveypeer-review

Abstract

Calixarenes have always captured the attention of several researchers. They have the ability to entrap multiple molecules and form inclusion complexes with drugs due to their unique structure. Due to this property, they are being widely used in the development of several classes of drugs, most notably anticancer drugs. This review attempted to summarize the potential applications of calixarenes and its derivatives in the development of anticancer drugs, with a focus on the delivery of drug classes such as DNA intercalators, taxanes, DNA alkylators, and topoisomerase inhibitors. Calixarene-based macromolecular chemistry could therefore have a high potential for overcoming the toxicity of cancer chemotherapy and achieving targeted drug delivery.

Original languageEnglish
Pages (from-to)939-945
Number of pages7
JournalMedicinal Chemistry
Volume19
Issue number10
DOIs
Publication statusPublished - 2023

All Science Journal Classification (ASJC) codes

  • Drug Discovery

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