TY - JOUR
T1 - Carbamazepine-induced life-threatening Stevens-Johnson Syndrome and Agranulocytosis
T2 - The maiden case
AU - Avinash, A.
AU - Mohanbabu Amberkar, V.
AU - Kunder, Sushil Kiran
AU - Madhyastha, Sharath
AU - Meena kumari, K.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Stevens-Johnson syndrome is one of the few dermatological emergencies in clinical practice. The syndrome is often secondary to the usage of drugs, of which allopurinol, penicillins, sulfa drugs, ibuprofen, sodium valproate, phenytoin, lamotrigine and carbamazepine are commonly implicated. Agranulocytosis is the existence of a clinically significant reduction in neutrophil count.This condition is a serious threat to the patient, as he/she is at a greater risk of contracting bacterial or fungal infections, which may prove to be fatal. The co-existence of Stevens-Johnson syndrome and agranulocytosis in the same patient further increases the risk of morbidity and mortality. To the best of our knowledge, there are no reports available in the existing literature, of cases that were reported with both these life-threatening conditions in a single patient, at the same point of time. This is a case narrative of a patient who presented with both Stevens-Johnson syndrome and agranulocytosis, following the administration of carbamazepine The patient’s differential leucocyte count revealed a neutrophil proportion of 2.33%. A causality assessment done using Naranjo’s algorithm showed that carbamazepine “definitely” caused Agranulocytosis and “probably” caused Stevens-Johnson Syndrome.
AB - Stevens-Johnson syndrome is one of the few dermatological emergencies in clinical practice. The syndrome is often secondary to the usage of drugs, of which allopurinol, penicillins, sulfa drugs, ibuprofen, sodium valproate, phenytoin, lamotrigine and carbamazepine are commonly implicated. Agranulocytosis is the existence of a clinically significant reduction in neutrophil count.This condition is a serious threat to the patient, as he/she is at a greater risk of contracting bacterial or fungal infections, which may prove to be fatal. The co-existence of Stevens-Johnson syndrome and agranulocytosis in the same patient further increases the risk of morbidity and mortality. To the best of our knowledge, there are no reports available in the existing literature, of cases that were reported with both these life-threatening conditions in a single patient, at the same point of time. This is a case narrative of a patient who presented with both Stevens-Johnson syndrome and agranulocytosis, following the administration of carbamazepine The patient’s differential leucocyte count revealed a neutrophil proportion of 2.33%. A causality assessment done using Naranjo’s algorithm showed that carbamazepine “definitely” caused Agranulocytosis and “probably” caused Stevens-Johnson Syndrome.
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U2 - 10.7860/JCDR/2016/23748.9065
DO - 10.7860/JCDR/2016/23748.9065
M3 - Article
AN - SCOPUS:85003955465
SN - 2249-782X
VL - 10
SP - FD01-FD03
JO - Journal of Clinical and Diagnostic Research
JF - Journal of Clinical and Diagnostic Research
IS - 12
ER -