TY - JOUR
T1 - Cefoperazone induced gastrointestinal bleeding
AU - Katukuri, Goutham Reddy
AU - Maddala, Raja Naga Mahesh
AU - Ramamoorthi, Kusugodlu
AU - Hande, Manjunatha
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Cefoperazone is a beta-lactam antibiotic which is frequently used in treating a variety of gram positive and gram negative infections. The chemical structure of cefoperazone contains a side chain of N-methylthiotetrazole which can inhibit vitamin K metabolism resulting in hypoprothombinemia. We report a case of cefoperazone induced coagulopathy manifesting as gastrointestinal bleeding. A Naranjo assessment score of 5 was obtained, indicating a probable relationship between the patient’s coagulation function disorder and her use of the suspect drug.
AB - Cefoperazone is a beta-lactam antibiotic which is frequently used in treating a variety of gram positive and gram negative infections. The chemical structure of cefoperazone contains a side chain of N-methylthiotetrazole which can inhibit vitamin K metabolism resulting in hypoprothombinemia. We report a case of cefoperazone induced coagulopathy manifesting as gastrointestinal bleeding. A Naranjo assessment score of 5 was obtained, indicating a probable relationship between the patient’s coagulation function disorder and her use of the suspect drug.
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U2 - 10.7860/JCDR/2016/19694.8316
DO - 10.7860/JCDR/2016/19694.8316
M3 - Article
AN - SCOPUS:84985920048
SN - 2249-782X
VL - 10
SP - OD10-OD11
JO - Journal of Clinical and Diagnostic Research
JF - Journal of Clinical and Diagnostic Research
IS - 8
ER -