Cefoperazone induced gastrointestinal bleeding

Goutham Reddy Katukuri, Raja Naga Mahesh Maddala, Kusugodlu Ramamoorthi, Manjunatha Hande

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Cefoperazone is a beta-lactam antibiotic which is frequently used in treating a variety of gram positive and gram negative infections. The chemical structure of cefoperazone contains a side chain of N-methylthiotetrazole which can inhibit vitamin K metabolism resulting in hypoprothombinemia. We report a case of cefoperazone induced coagulopathy manifesting as gastrointestinal bleeding. A Naranjo assessment score of 5 was obtained, indicating a probable relationship between the patient’s coagulation function disorder and her use of the suspect drug.

Original languageEnglish
Pages (from-to)OD10-OD11
JournalJournal of Clinical and Diagnostic Research
Issue number8
Publication statusPublished - 01-08-2016

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry


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