Cefoperzone - Sulbactum induced hypoprothrombinemia

Vijay Jaimni, Neha Agarwal, M. Sudhakar Rao, Sudha Vidyasagar

Research output: Contribution to journalArticlepeer-review


An elderly man who presented to the hospital with UTI and renal failure was given cefoperazone-sulbactum, subsequently developed hemetemesis and hematuria. Cefoperazone, a parenteral third generation cephalosporin is effective against many Gram positive and Gram negative organisms. Cefoperazone, similar to other cephalosporins such as cefamandole, contains the methyltiotetrazole (NMTT) side chain, which can cause hypoprothrombinaemia and consequently bleeding manifestations. This type of coagulation disorder usually responds to Vitamin K administration.

Original languageEnglish
Pages (from-to)1472-1475
Number of pages4
JournalResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Issue number4
Publication statusPublished - 01-07-2016

All Science Journal Classification (ASJC) codes

  • General Biochemistry,Genetics and Molecular Biology
  • Pharmacology, Toxicology and Pharmaceutics(all)


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