TY - JOUR
T1 - Centroblastic variant of diffuse large B-cell lymphoma
T2 - Case report and review of literature
AU - Nayak, Preethi
AU - Desai, Dinkar
AU - Pandit, Siddharth
AU - Rai, Nisha
PY - 2013/5
Y1 - 2013/5
N2 - Diffuse large B-cell lymphoma (DLBCL) is a subtype of non-Hodgkin's lymphoma (NHL) making up about approximately 30% of all NHL. Its occurrence in the mandible is very rare. Histopathologically, five variants of DLBCL have been recognized among which centroblastic variant is the one with better prognosis. We report a case of a 55 year-old patient who presented with a painless swelling in the lower right body of the mandible since 4 months. Incisional biopsy revealed NHL like features, confirmed by immunohistochemistry using CD45, CD20, and CD3 markers to be a DLBCL of centroblastic variant. Patient was treated with chemotherapy following which the lesion regressed completely with no further recurrences. Precise histological diagnosis is crucial for the clinical management and ultimately for the survival of the patient.
AB - Diffuse large B-cell lymphoma (DLBCL) is a subtype of non-Hodgkin's lymphoma (NHL) making up about approximately 30% of all NHL. Its occurrence in the mandible is very rare. Histopathologically, five variants of DLBCL have been recognized among which centroblastic variant is the one with better prognosis. We report a case of a 55 year-old patient who presented with a painless swelling in the lower right body of the mandible since 4 months. Incisional biopsy revealed NHL like features, confirmed by immunohistochemistry using CD45, CD20, and CD3 markers to be a DLBCL of centroblastic variant. Patient was treated with chemotherapy following which the lesion regressed completely with no further recurrences. Precise histological diagnosis is crucial for the clinical management and ultimately for the survival of the patient.
UR - http://www.scopus.com/inward/record.url?scp=84886530841&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84886530841&partnerID=8YFLogxK
U2 - 10.4103/0973-029X.119749
DO - 10.4103/0973-029X.119749
M3 - Article
AN - SCOPUS:84886530841
SN - 0973-029X
VL - 17
SP - 261
EP - 265
JO - Journal of Oral and Maxillofacial Pathology
JF - Journal of Oral and Maxillofacial Pathology
IS - 2
ER -