Centroblastic variant of diffuse large B-cell lymphoma: Case report and review of literature

Preethi Nayak, Dinkar Desai, Siddharth Pandit, Nisha Rai

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Diffuse large B-cell lymphoma (DLBCL) is a subtype of non-Hodgkin's lymphoma (NHL) making up about approximately 30% of all NHL. Its occurrence in the mandible is very rare. Histopathologically, five variants of DLBCL have been recognized among which centroblastic variant is the one with better prognosis. We report a case of a 55 year-old patient who presented with a painless swelling in the lower right body of the mandible since 4 months. Incisional biopsy revealed NHL like features, confirmed by immunohistochemistry using CD45, CD20, and CD3 markers to be a DLBCL of centroblastic variant. Patient was treated with chemotherapy following which the lesion regressed completely with no further recurrences. Precise histological diagnosis is crucial for the clinical management and ultimately for the survival of the patient.

Original languageEnglish
Pages (from-to)261-265
Number of pages5
JournalJournal of Oral and Maxillofacial Pathology
Issue number2
Publication statusPublished - 05-2013

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Otorhinolaryngology


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