Abstract
This chapter provides an overview of chalcones as molecular probes in chemical biology and bioimaging. Chalcones, known for their biological activities like antioxidant, antiinflammatory, and anticancer effects, also hold significant potential for exploring cellular processes. Their structural diversity and ability to undergo various chemical reactions make them ideal for studying protein interactions, enzyme activity, and cellular pathways in diseases such as cancer and neurodegenerative disorders. Furthermore chalcones’ intrinsic fluorescence allows their use in bioimaging techniques, including fluorescence microscopy and live-cell imaging. The chapter also discusses challenges, such as stability and selectivity, and highlights strategies like structure-activity relationship studies to optimize chalcones for these applications. Ultimately, it emphasizes the need for further research to fully harness their capabilities as versatile molecular probes in chemical biology and bioimaging.
| Original language | English |
|---|---|
| Title of host publication | Chalcones and their Derivatives |
| Subtitle of host publication | From Synthesis to Applications |
| Publisher | Elsevier |
| Pages | 371-404 |
| Number of pages | 34 |
| ISBN (Electronic) | 9780443301223 |
| ISBN (Print) | 9780443301230 |
| DOIs | |
| Publication status | Published - 01-01-2025 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
All Science Journal Classification (ASJC) codes
- General Chemistry
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