TY - JOUR
T1 - Changing trends of lower respiratory tract pathogens
T2 - A Five year Study
AU - Shenoy Padmaja, A.
AU - Purandare Mrudghandha, K.
AU - Kiran, Chawla
N1 - Publisher Copyright:
©Annals of Tropical Medicine & Public Health-Special Issues
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Context: Lower respiratory tract infections (LRTIs) are one of the most common problems encountered by physicians posing huge impact on health care system. Among the diverse respiratory bacterial etiological agents, Gram-negative bacilli predominate in developing countries. Antimicrobial resistance among the respiratory pathogens is a raising concern leading to prolonged hospital stay and high morbidity/mortality. Aims: The aim of the study was to determine the common bacterial aetiological agents causing LRTIs and to study their changing trends of antibiotic resistance pattern. Settings and design: Retrospective study was conducted from January 2012 to December 2016 in Department of Microbiology, tertiary care teaching hospital, Manipal. Methods and materials: Respiratory specimens including Broncho alveolar Lavage (BAL), Endotracheal (ET) aspirate and sputum samples were processed for Gram stain and culture. The respiratory pathogens were identified and were subjected to antibiotic susceptibility testing following standard techniques. Statistical analysis used: Obtained results were analysed by SPSS version 16. Changing trends of antibiotic resistance was studied by linear regression. Results: Of the 22095 samples received, significant bacterial growth was observed in 6766 (30.6%) specimens. Gram-negatives (5581, 82.5%) outnumbered the Gram- positive isolates (1156, 17%). Among the Gram-negative bacilli (5581, 82.5%), non-fermenters were (3297, 59%) predominantly isolated followed by members of Enterobacteriaceae (1622, 29%). Among the non-fermenters, Acinetobacter baumannii was the frequent isolate (1696, 51.4%) showing significant increasing trends of resistance to cefoperazone-sulbactam (R2= 0.85 and P value 0.03) and maximum increase in antibiotic resistance was observed in the year 2016 (77%). Conclusion: Significant upsurge in the resistance trends of common antibiotics in LRTIs calls for judicious usage of antibiotics & strict infection control practices.
AB - Context: Lower respiratory tract infections (LRTIs) are one of the most common problems encountered by physicians posing huge impact on health care system. Among the diverse respiratory bacterial etiological agents, Gram-negative bacilli predominate in developing countries. Antimicrobial resistance among the respiratory pathogens is a raising concern leading to prolonged hospital stay and high morbidity/mortality. Aims: The aim of the study was to determine the common bacterial aetiological agents causing LRTIs and to study their changing trends of antibiotic resistance pattern. Settings and design: Retrospective study was conducted from January 2012 to December 2016 in Department of Microbiology, tertiary care teaching hospital, Manipal. Methods and materials: Respiratory specimens including Broncho alveolar Lavage (BAL), Endotracheal (ET) aspirate and sputum samples were processed for Gram stain and culture. The respiratory pathogens were identified and were subjected to antibiotic susceptibility testing following standard techniques. Statistical analysis used: Obtained results were analysed by SPSS version 16. Changing trends of antibiotic resistance was studied by linear regression. Results: Of the 22095 samples received, significant bacterial growth was observed in 6766 (30.6%) specimens. Gram-negatives (5581, 82.5%) outnumbered the Gram- positive isolates (1156, 17%). Among the Gram-negative bacilli (5581, 82.5%), non-fermenters were (3297, 59%) predominantly isolated followed by members of Enterobacteriaceae (1622, 29%). Among the non-fermenters, Acinetobacter baumannii was the frequent isolate (1696, 51.4%) showing significant increasing trends of resistance to cefoperazone-sulbactam (R2= 0.85 and P value 0.03) and maximum increase in antibiotic resistance was observed in the year 2016 (77%). Conclusion: Significant upsurge in the resistance trends of common antibiotics in LRTIs calls for judicious usage of antibiotics & strict infection control practices.
UR - https://www.scopus.com/pages/publications/85069773791
UR - https://www.scopus.com/inward/citedby.url?scp=85069773791&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85069773791
SN - 1755-6783
VL - 19
JO - Annals of Tropical Medicine and Public Health
JF - Annals of Tropical Medicine and Public Health
IS - Special Issue
ER -
