Chemical and pharmacological investigations of limnophila conferta and limnophila heterophylla

G. B.S. Reddy; A. B. Melkhani; G. A. Kalyani; J. Venkata Rao; Annie Shirwaikar; Mohan Kotian; Rama Ramani; K. S. Aithal; A. L. Udupa; Gopalakrishna Bhat; K. K. Srinivasan

doi:10.3109/13880209109082868

Chemical and pharmacological investigations of limnophila conferta and limnophila heterophylla

G. B.S. Reddy, A. B. Melkhani, G. A. Kalyani, J. Venkata Rao, Annie Shirwaikar, Mohan Kotian, Rama Ramani, K. S. Aithal, A. L. Udupa, Gopalakrishna Bhat, K. K. Srinivasan

Research output: Contribution to journal › Article › peer-review

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Abstract

Fifteen components of the essential Oil of L. conferta were identified by GC-MS analysis. The main components were identified to be a-phcllandrene (52.2% and thymol (38.2% The antifungal activity at 1:50 dilution in ethylene glycol was found to be of the same order as that of griseofulvin (1001Jg/ 0.1 ml). The oil also possessed good anthelmintic activity. The crude alcoholic extract after the removal of the oil showed significant reduction in the epithelisation period compared to that of controls in excision wound models. Nevadensin isolated from the plant showed good anti-inflammatory activity in an acute inflammation model, and exhibited moderate cytotoxic activity and anti-tubercular activity. L. heterophylla on chemical analysis afforded hymenoxin.

Original language	English
Pages (from-to)	145-153
Number of pages	9
Journal	Pharmaceutical Biology
Volume	29
Issue number	2
DOIs	https://doi.org/10.3109/13880209109082868
Publication status	Published - 1991

All Science Journal Classification (ASJC) codes

Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine

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title = "Chemical and pharmacological investigations of limnophila conferta and limnophila heterophylla",

abstract = "Fifteen components of the essential Oil of L. conferta were identified by GC-MS analysis. The main components were identified to be a-phcllandrene (52.2% and thymol (38.2% The antifungal activity at 1:50 dilution in ethylene glycol was found to be of the same order as that of griseofulvin (1001Jg/ 0.1 ml). The oil also possessed good anthelmintic activity. The crude alcoholic extract after the removal of the oil showed significant reduction in the epithelisation period compared to that of controls in excision wound models. Nevadensin isolated from the plant showed good anti-inflammatory activity in an acute inflammation model, and exhibited moderate cytotoxic activity and anti-tubercular activity. L. heterophylla on chemical analysis afforded hymenoxin.",

author = "Reddy, {G. B.S.} and Melkhani, {A. B.} and Kalyani, {G. A.} and Rao, {J. Venkata} and Annie Shirwaikar and Mohan Kotian and Rama Ramani and Aithal, {K. S.} and Udupa, {A. L.} and Gopalakrishna Bhat and Srinivasan, {K. K.}",

year = "1991",

doi = "10.3109/13880209109082868",

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T1 - Chemical and pharmacological investigations of limnophila conferta and limnophila heterophylla

AU - Reddy, G. B.S.

AU - Melkhani, A. B.

AU - Kalyani, G. A.

AU - Rao, J. Venkata

AU - Shirwaikar, Annie

AU - Kotian, Mohan

AU - Ramani, Rama

AU - Aithal, K. S.

AU - Udupa, A. L.

AU - Bhat, Gopalakrishna

AU - Srinivasan, K. K.

PY - 1991

Y1 - 1991

N2 - Fifteen components of the essential Oil of L. conferta were identified by GC-MS analysis. The main components were identified to be a-phcllandrene (52.2% and thymol (38.2% The antifungal activity at 1:50 dilution in ethylene glycol was found to be of the same order as that of griseofulvin (1001Jg/ 0.1 ml). The oil also possessed good anthelmintic activity. The crude alcoholic extract after the removal of the oil showed significant reduction in the epithelisation period compared to that of controls in excision wound models. Nevadensin isolated from the plant showed good anti-inflammatory activity in an acute inflammation model, and exhibited moderate cytotoxic activity and anti-tubercular activity. L. heterophylla on chemical analysis afforded hymenoxin.

AB - Fifteen components of the essential Oil of L. conferta were identified by GC-MS analysis. The main components were identified to be a-phcllandrene (52.2% and thymol (38.2% The antifungal activity at 1:50 dilution in ethylene glycol was found to be of the same order as that of griseofulvin (1001Jg/ 0.1 ml). The oil also possessed good anthelmintic activity. The crude alcoholic extract after the removal of the oil showed significant reduction in the epithelisation period compared to that of controls in excision wound models. Nevadensin isolated from the plant showed good anti-inflammatory activity in an acute inflammation model, and exhibited moderate cytotoxic activity and anti-tubercular activity. L. heterophylla on chemical analysis afforded hymenoxin.

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ER -

Chemical and pharmacological investigations of limnophila conferta and limnophila heterophylla

Abstract

All Science Journal Classification (ASJC) codes

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