TY - JOUR
T1 - Chemical investigation, anti-inflammatory and wound healing properties of Coronopus didymus
AU - Prabhakar, K.R.
AU - Srinivasan, K.K.
AU - Rao, P.G.M.
N1 - Cited By :18
Export Date: 10 November 2017
CODEN: PHBIF
Correspondence Address: Srinivasan, K.K.; Dept. of Pharmaceutical Chemistry, College of Pharmaceutics Sciences, Manipal-576119, Karnataka, India; email: [email protected]
Chemicals/CAS: alcohol, 64-17-5; benzyl isothiocyanate, 622-78-6; chrysoeriol, 491-71-4; sitostanol, 19044-02-1, 83-45-4
References: Budzikiewicz, H., Djerassi, C., Mass spectrometry in structural and stereochemical problems. I. Steroid ketones (1962) J Am Chem Soc, 84, pp. 1169-1182; De Ruiz, R.E.L., Fusco, M., Sosa, A., Ruiz, S.O., Constituents of Coronopus didymus (1994) Fitoterpia, 65, pp. 181-182; Ehrlich, H.P., Hunt, T.K., Effects of cortisone and vitamin A on wound healing (1969) Ann Surg, 170, pp. 203-206; Evans, W.C., (1989) Treas and Evan's Pharmacognosy, pp. 247-302. , London, Bailliere Tindall-Carell and Collier Mac Millan; Heleming, H., Wound healing and seratonin antagonist (1969) Abstact Surg Gynecol Obstet, 129, pp. 673-675; Composition of essential oil of coronopus didymus seeds (1989) J Chem Soc of Pakistan, 11, pp. 80-81. , Inam ul haque; Khan, M.S.Y., Javed, K., Khan, M.H., Chemical investigation of Coronopus didymus (Jungli hall or Panacholi) (1990) Indian J Nat Prod, 6 (2), pp. 18-20; Lee, K.H., Studies on the mechanism of action of salicylate. II. Retardation of wound healing by aspirin (1968) J Pharm Sci, 57, pp. 1042-1043; Madan, B.R., Khanna, N.K., Effect of creatinine on various experimentally induced inflammatory models (1979) Indian J Physiol Pharmacol, 17, pp. 191-192; Markham, K.R., (1982) Techniques of Flavonoid Identification, pp. 1-94. , Biological Techniques Series, eds., London, Academic Press; Markham, K.R., Mohan Chari, V., (1975) The Flavonoids: Advances in Research, pp. 19-131. , Harborne JB, Mabry TJ, eds., London, Chapman & Hall; McDowall, F.H., Mortan, I.D., McDowell, A.K.R., Land-cress taint in cream and butter (1947) New Zealand J Sci Technol, A28, pp. 305-307; Patil, P.A., Kulkarni, D.R., Effect of anti-proliferative agents on healing of incision wounds in rats (1985) Ind J Exp Biol, 23, pp. 149-150; Vogel, A.I., Infrared Nuclear magnetic resonance and mass spectrometry correlation tables (1991) Vogel's Text Book of Practical Organic Chemistry, 5th Ed, pp. 1412-1441. , Furniss BS, Hannaford AJ, Smith PWG, Tatchell AR, eds., London, ELBS
PY - 2002
Y1 - 2002
N2 - A systematic chemical investigation of Coronopus didymus was undertaken. A new flavone glycoside, viz., chrysoeriol-(6″-OAc)-4′-β-D-glucoside, along with free chrysoeriol and stigmastanol, were isolated and characterized on the basis of chemical and spectral studies. The ethanol and aqueous extracts of the whole plant were subjected to anti-inflammatory and wound healing activity studies. Both ethanol and aqueous extracts showed statistically significant wound healing activity, whereas only the aqueous extract showed significant anti-inflammatory activity.
AB - A systematic chemical investigation of Coronopus didymus was undertaken. A new flavone glycoside, viz., chrysoeriol-(6″-OAc)-4′-β-D-glucoside, along with free chrysoeriol and stigmastanol, were isolated and characterized on the basis of chemical and spectral studies. The ethanol and aqueous extracts of the whole plant were subjected to anti-inflammatory and wound healing activity studies. Both ethanol and aqueous extracts showed statistically significant wound healing activity, whereas only the aqueous extract showed significant anti-inflammatory activity.
U2 - 10.1076/phbi.40.7.490.14684
DO - 10.1076/phbi.40.7.490.14684
M3 - Article
SN - 1388-0209
VL - 40
SP - 490
EP - 493
JO - Pharmaceutical Biology
JF - Pharmaceutical Biology
IS - 7
ER -