Childhood onset nephrotic syndrome-a journey through two pregnancies

Nephrotic Syndrome (NS), a unique renal disease complex associated with heavy proteinuria (protein excretion >3.5 gm/day), hypoalbuminemia (<30 gm/L) and peripheral oedema is a rare entity in pregnancy with an incidence of about 0.012-0.025%. There have been very few reports of pregnancy with co-existing NS. We hereby report a case of steroid sensitive childhood onset NS, due to minimal change disease and her course through two pregnancies. While she had a relapse of NS during her first pregnancy, she sailed through her second pregnancy without relapse. Women with NS can have a good maternal and perinatal outcome with multidisciplinary approach, and pregnancy does not always worsen the existing NS by causing a relapse or disease progression.