TY - JOUR
T1 - Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment
AU - Sharifi-Rad, Javad
AU - Quispe, Cristina
AU - Butnariu, Monica
AU - Rotariu, Lia Sanda
AU - Sytar, Oksana
AU - Sestito, Simona
AU - Rapposelli, Simona
AU - Akram, Muhammad
AU - Iqbal, Mehwish
AU - Krishna, Akash
AU - Kumar, Nanjangud Venkatesh Anil
AU - Braga, Susana S.
AU - Cardoso, Susana M.
AU - Jafernik, Karolina
AU - Ekiert, Halina
AU - Cruz-Martins, Natália
AU - Szopa, Agnieszka
AU - Villagran, Marcelo
AU - Mardones, Lorena
AU - Martorell, Miquel
AU - Docea, Anca Oana
AU - Calina, Daniela
N1 - Funding Information:
Thanks are due to University of Aveiro and FCT/MCTES (Funda??o para a Ci?ncia e a Tecnologia, Minist?rio da Ci?ncia, Tecnologia e Ensino Superior) for general funding to LAQV-REQUIMTE (ref UIDB/50006/2020) and to the QOPNA research unit.
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - The study describes the current state of knowledge on nanotechnology and its utilization in medicine. The focus in this manuscript was on the properties, usage safety, and potentially valuable applications of chitosan-based nanomaterials. Chitosan nanoparticles have high importance in nanomedicine, biomedical engineering, discovery and development of new drugs. The manuscript reviewed the new studies regarding the use of chitosan-based nanoparticles for creating new release systems with improved bioavailability, increased specificity and sensitivity, and reduced pharmacological toxicity of drugs. Nowadays, effective cancer treatment is a global problem, and recent advances in nanomedicine are of great importance. Special attention was put on the application of chitosan nanoparticles in developing new system for anticancer drug delivery. Pre-clinical and clinical studies support the use of chitosan-based nanoparticles in nanomedicine. This manuscript overviews the last progresses regarding the utilization, stability, and bioavailability of drug nanoencapsulation with chitosan and their safety.
AB - The study describes the current state of knowledge on nanotechnology and its utilization in medicine. The focus in this manuscript was on the properties, usage safety, and potentially valuable applications of chitosan-based nanomaterials. Chitosan nanoparticles have high importance in nanomedicine, biomedical engineering, discovery and development of new drugs. The manuscript reviewed the new studies regarding the use of chitosan-based nanoparticles for creating new release systems with improved bioavailability, increased specificity and sensitivity, and reduced pharmacological toxicity of drugs. Nowadays, effective cancer treatment is a global problem, and recent advances in nanomedicine are of great importance. Special attention was put on the application of chitosan nanoparticles in developing new system for anticancer drug delivery. Pre-clinical and clinical studies support the use of chitosan-based nanoparticles in nanomedicine. This manuscript overviews the last progresses regarding the utilization, stability, and bioavailability of drug nanoencapsulation with chitosan and their safety.
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U2 - 10.1186/s12935-021-02025-4
DO - 10.1186/s12935-021-02025-4
M3 - Review article
AN - SCOPUS:85108837212
SN - 1475-2867
VL - 21
JO - Cancer Cell International
JF - Cancer Cell International
IS - 1
M1 - 318
ER -
