TY - JOUR
T1 - Chloramine-T (N-chloro-p-toluenesulfonamide sodium salt), a versatile reagent in organic synthesis and analytical chemistry
T2 - An up to date review
AU - Nayak, Yogeesha N.
AU - Gaonkar, Santosh L.
AU - Saleh, Ebraheem Abdu Musad
AU - Dawsari, Abdullah Mohammed A.L.
AU - Harshitha, null
AU - Husain, Kakul
AU - Hassan, Ismail
N1 - Funding Information:
The authors thank Manipal Academy of Higher Education for awarding Intramural research grant [MAHE/CDS/PHD/IMF/2019] to Dr. Santosh L. Gaonkar and TMA Pai PhD fellowship to Yogeesha N. Nayak and Prince Sattam Bin Abdulaziz University for financial support.
Publisher Copyright:
© 2022 The Author(s)
PY - 2022/3
Y1 - 2022/3
N2 - Chloramine-T (CAT), the sodium salt of N-chloro-p-toluenesulfonamide, is a low-cost mild oxidizing agent with a wide range of uses. Most importantly, it can be used in acidic, neutral, and basic conditions. As a result, it's been widely used in chemistry, particularly in organic synthesis and analytical chemistry. Chloramine-T acts as a source of halonium cation and nitrogen anion and thus acts as base and nucleophile. It reacts with a wide range of functional groups and carries different molecular transformations. This paper thoroughly summarises and highlights the synthetic and analytical effectiveness of CAT. This study focuses on current developments as well as some older techniques in which CAT has been employed as an oxidizing agent. This review article stretches a comprehensive profile of the CAT reagent in organic synthesis and analytical chemistry, which will be very useful for further research exploration in this field.
AB - Chloramine-T (CAT), the sodium salt of N-chloro-p-toluenesulfonamide, is a low-cost mild oxidizing agent with a wide range of uses. Most importantly, it can be used in acidic, neutral, and basic conditions. As a result, it's been widely used in chemistry, particularly in organic synthesis and analytical chemistry. Chloramine-T acts as a source of halonium cation and nitrogen anion and thus acts as base and nucleophile. It reacts with a wide range of functional groups and carries different molecular transformations. This paper thoroughly summarises and highlights the synthetic and analytical effectiveness of CAT. This study focuses on current developments as well as some older techniques in which CAT has been employed as an oxidizing agent. This review article stretches a comprehensive profile of the CAT reagent in organic synthesis and analytical chemistry, which will be very useful for further research exploration in this field.
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U2 - 10.1016/j.jscs.2021.101416
DO - 10.1016/j.jscs.2021.101416
M3 - Review article
AN - SCOPUS:85123859158
SN - 1319-6103
VL - 26
JO - Journal of Saudi Chemical Society
JF - Journal of Saudi Chemical Society
IS - 2
M1 - 101416
ER -