TY - JOUR
T1 - Cholecalciferol Exhibits no Antibacterial Effect on Staphylococcus aureus and Escherichia coli
T2 - An in vitro Study
AU - Kurian, Shilia Jacob
AU - Biswas, Avirup
AU - Kulavalli, Shrivathsa
AU - Aranjani, Jesil Mathew
AU - Pattanaik, Amrita
AU - Munisamy, Murali
AU - Saravu, Kavitha
AU - Rodrigues, Gabriel Sunil
AU - Miraj, Sonal Sekhar
N1 - Publisher Copyright:
© 2024 Bentham Science Publishers.
PY - 2024
Y1 - 2024
N2 - Background: The pleiotropic effect of cholecalciferol (vitamin D3) has gained significant momentum and has been explored widely. Objectives: The study aimed to investigate the antimicrobial effect of cholecalciferol against S. aureus and E. coli. Methods: An in vitro study was performed for the antimicrobial effect of cholecalciferol against S. aureus and E. coli. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined following the broth microdilution method. Results: The MIC value of cholecalciferol against both S. aureus and E. coli was 0.312 mg/ml, and the MBC for both organisms was 1.25 mg/ml. However, we also observed a significant antimicrobial effect in the dimethyl sulfoxide (DMSO) control at 12.5% (v/v). Therefore, the observed antimicrobial effect may be attributed to DMSO, indicating cholecalciferol does not directly inhibit S. aureus and E. coli. Conclusion: This study indicates that cholecalciferol does not directly inhibit S. aureus and E. coli. Hence, we suggest exploring the antibacterial properties of other vitamin D analogs, such as calcitriol or its synergetic effect with other antimicrobial agents.
AB - Background: The pleiotropic effect of cholecalciferol (vitamin D3) has gained significant momentum and has been explored widely. Objectives: The study aimed to investigate the antimicrobial effect of cholecalciferol against S. aureus and E. coli. Methods: An in vitro study was performed for the antimicrobial effect of cholecalciferol against S. aureus and E. coli. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined following the broth microdilution method. Results: The MIC value of cholecalciferol against both S. aureus and E. coli was 0.312 mg/ml, and the MBC for both organisms was 1.25 mg/ml. However, we also observed a significant antimicrobial effect in the dimethyl sulfoxide (DMSO) control at 12.5% (v/v). Therefore, the observed antimicrobial effect may be attributed to DMSO, indicating cholecalciferol does not directly inhibit S. aureus and E. coli. Conclusion: This study indicates that cholecalciferol does not directly inhibit S. aureus and E. coli. Hence, we suggest exploring the antibacterial properties of other vitamin D analogs, such as calcitriol or its synergetic effect with other antimicrobial agents.
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U2 - 10.2174/0127724344277290231211051800
DO - 10.2174/0127724344277290231211051800
M3 - Article
C2 - 38275070
AN - SCOPUS:85193216364
SN - 2772-4344
VL - 19
SP - 315
EP - 321
JO - Recent Advances in Anti-Infective Drug Discovery
JF - Recent Advances in Anti-Infective Drug Discovery
IS - 4
ER -
