Cisplatin-etoposide induced myocardial infarction in a patient with small cell carcinoma

Srija Katta; Sheetal Chauhan; Ajit Singh; Prasad N. Shetty; Hashir Kareem; Tom Devasia

doi:10.7324/JAPS.2018.8519

Cisplatin-etoposide induced myocardial infarction in a patient with small cell carcinoma

Srija Katta, Sheetal Chauhan, Ajit Singh^*, Prasad N. Shetty, Hashir Kareem, Tom Devasia

^*Corresponding author for this work

Department of Cardiology, Kasturba Medical College, Manipal

Research output: Contribution to journal › Article › peer-review

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Abstract

Various drugs used to treat cancer cause hemodynamic/physiological changes in various organs of the body. Cardiotoxicity is one of the major side effects. Cardiotoxicity associated with chemotherapy can range from asymptomatic sub-clinical echocardiographic changes to life-threatening events like congestive heart failure or acute coronary syndrome. We present a case of cisplatin and etoposide-induced myocardial infarction (MI) during the second cycle of chemotherapy for bronchogenic carcinoma of the left lung (small cell carcinoma). The patient developed troponin positive NSTEMI and was managed conservatively. Here, the possible mechanism of action and the importance of cardiac screening while using cisplatin and etoposide are discussed.

Original language	English
Pages (from-to)	139-142
Number of pages	4
Journal	Journal of Applied Pharmaceutical Science
Volume	8
Issue number	5
DOIs	https://doi.org/10.7324/JAPS.2018.8519
Publication status	Published - 01-05-2018

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)
Pharmacology, Toxicology and Pharmaceutics(all)
Pharmacology (medical)

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10.7324/JAPS.2018.8519

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abstract = "Various drugs used to treat cancer cause hemodynamic/physiological changes in various organs of the body. Cardiotoxicity is one of the major side effects. Cardiotoxicity associated with chemotherapy can range from asymptomatic sub-clinical echocardiographic changes to life-threatening events like congestive heart failure or acute coronary syndrome. We present a case of cisplatin and etoposide-induced myocardial infarction (MI) during the second cycle of chemotherapy for bronchogenic carcinoma of the left lung (small cell carcinoma). The patient developed troponin positive NSTEMI and was managed conservatively. Here, the possible mechanism of action and the importance of cardiac screening while using cisplatin and etoposide are discussed.",

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AU - Kareem, Hashir

AU - Devasia, Tom

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AB - Various drugs used to treat cancer cause hemodynamic/physiological changes in various organs of the body. Cardiotoxicity is one of the major side effects. Cardiotoxicity associated with chemotherapy can range from asymptomatic sub-clinical echocardiographic changes to life-threatening events like congestive heart failure or acute coronary syndrome. We present a case of cisplatin and etoposide-induced myocardial infarction (MI) during the second cycle of chemotherapy for bronchogenic carcinoma of the left lung (small cell carcinoma). The patient developed troponin positive NSTEMI and was managed conservatively. Here, the possible mechanism of action and the importance of cardiac screening while using cisplatin and etoposide are discussed.

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Cisplatin-etoposide induced myocardial infarction in a patient with small cell carcinoma

Abstract

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