Cisplatin induced hyponatremic seizures secondary to SIADH (Syndrome of inappropriate Antidiuretic hormone secretion): A rare presentation

Anshul Singh; M. S. Vidyasagar; Anusha Reddy; H. Y. Prahlad; Navin Patil; Talha Ahmed

Cisplatin induced hyponatremic seizures secondary to SIADH (Syndrome of inappropriate Antidiuretic hormone secretion): A rare presentation

Anshul Singh, M. S. Vidyasagar, Anusha Reddy, H. Y. Prahlad, Navin Patil, Talha Ahmed

Research output: Contribution to journal › Article › peer-review

Abstract

We report a case of a patient aged 65 years' who presented with histopathological proven metastatic squamous cell cancer of the anal canal. After the necessary workup she was planned for Cisplatin and Fluoropyrimidine based palliative chemotherapy. On day 4 following chemotherapy the patient developed an episode of Generalized Tonic Clonic Seizures, which on further evaluation was attributed to hyponatremia as a result of SIADH secondary to Cisplatin. She required ICU care but made a complete recovery. Patient subsequently refused IV chemotherapy, thereafter she was managed on single agent oral capecitabine and is on follow up to date.

Original language	English
Pages (from-to)	1132-1135
Number of pages	4
Journal	Research Journal of Pharmaceutical, Biological and Chemical Sciences
Volume	6
Issue number	6
Publication status	Published - 01-01-2015

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Cisplatin induced hyponatremic seizures secondary to SIADH (Syndrome of inappropriate Antidiuretic hormone secretion): A rare presentation",

abstract = "We report a case of a patient aged 65 years' who presented with histopathological proven metastatic squamous cell cancer of the anal canal. After the necessary workup she was planned for Cisplatin and Fluoropyrimidine based palliative chemotherapy. On day 4 following chemotherapy the patient developed an episode of Generalized Tonic Clonic Seizures, which on further evaluation was attributed to hyponatremia as a result of SIADH secondary to Cisplatin. She required ICU care but made a complete recovery. Patient subsequently refused IV chemotherapy, thereafter she was managed on single agent oral capecitabine and is on follow up to date.",

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Cisplatin induced hyponatremic seizures secondary to SIADH (Syndrome of inappropriate Antidiuretic hormone secretion): A rare presentation. / Singh, Anshul ; Vidyasagar, M. S.; Reddy, Anusha et al.
In: Research Journal of Pharmaceutical, Biological and Chemical Sciences, Vol. 6, No. 6, 01.01.2015, p. 1132-1135.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Cisplatin induced hyponatremic seizures secondary to SIADH (Syndrome of inappropriate Antidiuretic hormone secretion)

T2 - A rare presentation

AU - Singh, Anshul

AU - Vidyasagar, M. S.

AU - Reddy, Anusha

AU - Prahlad, H. Y.

AU - Patil, Navin

AU - Ahmed, Talha

PY - 2015/1/1

Y1 - 2015/1/1

N2 - We report a case of a patient aged 65 years' who presented with histopathological proven metastatic squamous cell cancer of the anal canal. After the necessary workup she was planned for Cisplatin and Fluoropyrimidine based palliative chemotherapy. On day 4 following chemotherapy the patient developed an episode of Generalized Tonic Clonic Seizures, which on further evaluation was attributed to hyponatremia as a result of SIADH secondary to Cisplatin. She required ICU care but made a complete recovery. Patient subsequently refused IV chemotherapy, thereafter she was managed on single agent oral capecitabine and is on follow up to date.

AB - We report a case of a patient aged 65 years' who presented with histopathological proven metastatic squamous cell cancer of the anal canal. After the necessary workup she was planned for Cisplatin and Fluoropyrimidine based palliative chemotherapy. On day 4 following chemotherapy the patient developed an episode of Generalized Tonic Clonic Seizures, which on further evaluation was attributed to hyponatremia as a result of SIADH secondary to Cisplatin. She required ICU care but made a complete recovery. Patient subsequently refused IV chemotherapy, thereafter she was managed on single agent oral capecitabine and is on follow up to date.

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M3 - Article

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JF - Research Journal of Pharmaceutical, Biological and Chemical Sciences

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Cisplatin induced hyponatremic seizures secondary to SIADH (Syndrome of inappropriate Antidiuretic hormone secretion): A rare presentation

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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