Clinical and laboratory profile of patients with Kyasanur forest disease: A single-centre study of 192 patients from Karnataka, India

Introduction: Kyasanur forest disease (KFD) is a biphasic tick-borne viral fever that is endemic to 16 districts and five states of Southern India. The aim of this study was to describe the clinical/ laboratory manifestations of KFD. Materials and Methods: This is a retrospective cohort study of confirmed KFD patients admitted in our hospital between December 2018 and June 2019. The demographic, clinical and laboratory parameters of patients during the first and second phase of illness was recorded in a pre-defined case study form. Results: A total of 192 patients from Karnataka were diagnosed with a mean age of 46.2 ± 15.6 years and a male preponderance (57 %). Fever (99 %), myalgia (52 %), headache (43 %), cough (14 %), conjunctival congestion (14 %), altered sensorium (13 %) and haemorrhagic manifestations (8%) were seen in the first phase. A total of 18 % of the patients came back with a second febrile episode. The features of meningoencephalitis were seen in 34 % of the patients during the second phase. Leucopenia, thrombocytopenia, and increase in liver enzymes, creatine phosphokinase (CPK) and activated partial thromboplastin time (APTT) was seen in the first phase but not in the second phase. Higher age, myocarditis, altered sensorium in the first phase, hypotension at admission, lower platelet count, elevated liver enzymes, higher APTT and CPK, were significantly associated with mortality. Conclusion: The primary care physicians or travel medicine practitioners should be aware of the distinct clinical and laboratory manifestations of KFD, including the ones that may signify requirements of higher levels of care.