Clinical, Immunological, and Molecular Profile of Chronic Granulomatous Disease: A Multi-Centric Study of 236 Patients From India

Amit Rawat; Pandiarajan Vignesh; Madhubala Sharma; Deepti Suri; Ankur Kumar Jindal; Anju Gupta; Jitendra Kumar Shandilya; Biman Saikia; Prasad  Taur; Ambreen Pandrowala; Vijaya Gowri; Mukesh Desai; Manasi Kulkarni; Umair Bargir; Priyanka  Kambli; Manisha Madkaikar; Sagar  Bhattad; Ananthvikas Jayaram; Deenadayalan Munirathnam; Meena Sivasankaran; Revathi Raj; Ramya  Uppuluri; Harsha P Lashkari; Manas Kalra; Anupam Sachdeva; Koon Wing Chan; Kohsuke Imai; Osamu Ohara; Shigeaki Nonoyama; Yu Lung Lau; Surjit Singh

doi:10.3389/fimmu.2021.625320

Clinical, Immunological, and Molecular Profile of Chronic Granulomatous Disease: A Multi-Centric Study of 236 Patients From India

Amit Rawat, Pandiarajan Vignesh, Madhubala Sharma, Deepti Suri, Ankur Kumar Jindal, Anju Gupta, Jitendra Kumar Shandilya, Biman Saikia, Prasad Taur, Ambreen Pandrowala, Vijaya Gowri, Mukesh Desai, Manasi Kulkarni, Umair Bargir, Priyanka Kambli, Manisha Madkaikar, Sagar Bhattad, Ananthvikas Jayaram, Deenadayalan Munirathnam, Meena SivasankaranRevathi Raj, Ramya Uppuluri, Harsha P Lashkari, Manas Kalra, Anupam Sachdeva, Koon Wing Chan, Kohsuke Imai, Osamu Ohara, Shigeaki Nonoyama, Yu Lung Lau, Surjit Singh

Department of Paediatrics, Kasturba Medical College, Mangalore

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Chronic granulomatous disease (CGD) is an inherited defect in phagocytic
respiratory burst that results in severe and life-threatening infections in affected children. Single center studies from India have shown that proportion of autosomal recessive (AR) CGD is more than that reported from the West. Further, affected patients have high mortality rates due to late referrals and difficulties in accessing appropriate treatment. However, there is lack of multicentric collaborative data on CGD from India.

Original language	English
Article number	625320
Journal	Frontiers in Immunology
DOIs	https://doi.org/10.3389/fimmu.2021.625320
Publication status	Published - 25-02-2021

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Rawat, A., Vignesh, P., Sharma, M., Suri, D., Jindal, A. K., Gupta, A., Shandilya, J. K., Saikia, B., Taur, P., Pandrowala, A., Gowri, V., Desai, M., Kulkarni, M., Bargir, U., Kambli, P., Madkaikar, M., Bhattad, S., Jayaram, A., Munirathnam, D., ... Singh, S. (2021). Clinical, Immunological, and Molecular Profile of Chronic Granulomatous Disease: A Multi-Centric Study of 236 Patients From India. Frontiers in Immunology, [625320]. https://doi.org/10.3389/fimmu.2021.625320

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title = "Clinical, Immunological, and Molecular Profile of Chronic Granulomatous Disease: A Multi-Centric Study of 236 Patients From India",

abstract = "Chronic granulomatous disease (CGD) is an inherited defect in phagocyticrespiratory burst that results in severe and life-threatening infections in affected children. Single center studies from India have shown that proportion of autosomal recessive (AR) CGD is more than that reported from the West. Further, affected patients have high mortality rates due to late referrals and difficulties in accessing appropriate treatment. However, there is lack of multicentric collaborative data on CGD from India.",

author = "Amit Rawat and Pandiarajan Vignesh and Madhubala Sharma and Deepti Suri and Jindal, {Ankur Kumar} and Anju Gupta and Shandilya, {Jitendra Kumar} and Biman Saikia and Prasad Taur and Ambreen Pandrowala and Vijaya Gowri and Mukesh Desai and Manasi Kulkarni and Umair Bargir and Priyanka Kambli and Manisha Madkaikar and Sagar Bhattad and Ananthvikas Jayaram and Deenadayalan Munirathnam and Meena Sivasankaran and Revathi Raj and Ramya Uppuluri and Lashkari, {Harsha P} and Manas Kalra and Anupam Sachdeva and Chan, {Koon Wing} and Kohsuke Imai and Osamu Ohara and Shigeaki Nonoyama and Lau, {Yu Lung} and Surjit Singh",

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month = feb,

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doi = "10.3389/fimmu.2021.625320",

language = "English",

journal = "Frontiers in Immunology",

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Rawat, A, Vignesh, P, Sharma, M, Suri, D, Jindal, AK, Gupta, A, Shandilya, JK, Saikia, B, Taur, P, Pandrowala, A, Gowri, V, Desai, M, Kulkarni, M, Bargir, U, Kambli, P, Madkaikar, M, Bhattad, S, Jayaram, A, Munirathnam, D, Sivasankaran, M, Raj, R, Uppuluri, R, Lashkari, HP, Kalra, M, Sachdeva, A, Chan, KW, Imai, K, Ohara, O, Nonoyama, S, Lau, YL & Singh, S 2021, 'Clinical, Immunological, and Molecular Profile of Chronic Granulomatous Disease: A Multi-Centric Study of 236 Patients From India', Frontiers in Immunology. https://doi.org/10.3389/fimmu.2021.625320

TY - JOUR

T1 - Clinical, Immunological, and Molecular Profile of Chronic Granulomatous Disease: A Multi-Centric Study of 236 Patients From India

AU - Rawat, Amit

AU - Vignesh, Pandiarajan

AU - Sharma, Madhubala

AU - Suri, Deepti

AU - Jindal, Ankur Kumar

AU - Gupta, Anju

AU - Shandilya, Jitendra Kumar

AU - Saikia, Biman

AU - Taur, Prasad

AU - Pandrowala, Ambreen

AU - Gowri, Vijaya

AU - Desai, Mukesh

AU - Kulkarni, Manasi

AU - Bargir, Umair

AU - Kambli, Priyanka

AU - Madkaikar, Manisha

AU - Bhattad, Sagar

AU - Jayaram, Ananthvikas

AU - Munirathnam, Deenadayalan

AU - Sivasankaran, Meena

AU - Raj, Revathi

AU - Uppuluri, Ramya

AU - Lashkari, Harsha P

AU - Kalra, Manas

AU - Sachdeva, Anupam

AU - Chan, Koon Wing

AU - Imai, Kohsuke

AU - Ohara, Osamu

AU - Nonoyama, Shigeaki

AU - Lau, Yu Lung

AU - Singh, Surjit

PY - 2021/2/25

Y1 - 2021/2/25

N2 - Chronic granulomatous disease (CGD) is an inherited defect in phagocyticrespiratory burst that results in severe and life-threatening infections in affected children. Single center studies from India have shown that proportion of autosomal recessive (AR) CGD is more than that reported from the West. Further, affected patients have high mortality rates due to late referrals and difficulties in accessing appropriate treatment. However, there is lack of multicentric collaborative data on CGD from India.

AB - Chronic granulomatous disease (CGD) is an inherited defect in phagocyticrespiratory burst that results in severe and life-threatening infections in affected children. Single center studies from India have shown that proportion of autosomal recessive (AR) CGD is more than that reported from the West. Further, affected patients have high mortality rates due to late referrals and difficulties in accessing appropriate treatment. However, there is lack of multicentric collaborative data on CGD from India.

U2 - 10.3389/fimmu.2021.625320

DO - 10.3389/fimmu.2021.625320

M3 - Article

SN - 1664-3224

JO - Frontiers in Immunology

JF - Frontiers in Immunology

M1 - 625320

ER -

Clinical, Immunological, and Molecular Profile of Chronic Granulomatous Disease: A Multi-Centric Study of 236 Patients From India

Abstract

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