TY - JOUR
T1 - Clinical, laboratory, and molecular epidemiology of Orientia tsutsugamushi infection from Southwestern India
AU - Chunduru, Kiran
AU - A R, Manoj
AU - Poornima, Subhadra
AU - Hande H, Manjunatha
AU - M, Mridula
AU - Varghese, George M.
AU - Devaki, Ramakrishna
AU - Saravu, Kavitha
N1 - Funding Information:
KS has received funding from Science and Engineering Research Board (SERB) (www. serbonline.in), Government of India (File No. CRG/2020/001471) to carry out the study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
© 2023 Chunduru et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2023/7
Y1 - 2023/7
N2 - Scrub typhus is a vector borne disease which in a proportion of patients causes multiorgan involvement and death if untreated. Infecting genotype and virulence factors play a role in severity of infection and outcome. The current prospective cohort study was undertaken to elucidate the severity of illness in scrub typhus patients and to identify the circulating genotypes in Karnataka, India. A total of 214 patients of either gender from 9 districts of Karnataka and one patient each from Andhra Pradesh and Kerala, India were enrolled in the study. With a predefined severity criterion, 132 patients were segregated to the severe group. Multi organ involvement was seen in 59 (44.69%) patients. Phylogenetic analysis revealed JG-v like (48.97%), Karp-like (26.53%), JG-like (22.44%), and Kato-like (2.04%) strains in Karnataka. Patients infected with Orientia tsutsugamushi Karp-like strains had respiratory involvement (69.2%), cardiovascular involvement (46.2%) and thrombocytopenia (23.1%) and required higher hospital resource utilization.
AB - Scrub typhus is a vector borne disease which in a proportion of patients causes multiorgan involvement and death if untreated. Infecting genotype and virulence factors play a role in severity of infection and outcome. The current prospective cohort study was undertaken to elucidate the severity of illness in scrub typhus patients and to identify the circulating genotypes in Karnataka, India. A total of 214 patients of either gender from 9 districts of Karnataka and one patient each from Andhra Pradesh and Kerala, India were enrolled in the study. With a predefined severity criterion, 132 patients were segregated to the severe group. Multi organ involvement was seen in 59 (44.69%) patients. Phylogenetic analysis revealed JG-v like (48.97%), Karp-like (26.53%), JG-like (22.44%), and Kato-like (2.04%) strains in Karnataka. Patients infected with Orientia tsutsugamushi Karp-like strains had respiratory involvement (69.2%), cardiovascular involvement (46.2%) and thrombocytopenia (23.1%) and required higher hospital resource utilization.
UR - http://www.scopus.com/inward/record.url?scp=85165709150&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85165709150&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0289126
DO - 10.1371/journal.pone.0289126
M3 - Article
C2 - 37490497
AN - SCOPUS:85165709150
SN - 1932-6203
VL - 18
SP - e0289126
JO - PLoS One
JF - PLoS One
IS - 7 July
M1 - e0289126
ER -