1 Citation (Scopus)

Abstract

Scrub typhus is a vector borne disease which in a proportion of patients causes multiorgan involvement and death if untreated. Infecting genotype and virulence factors play a role in severity of infection and outcome. The current prospective cohort study was undertaken to elucidate the severity of illness in scrub typhus patients and to identify the circulating genotypes in Karnataka, India. A total of 214 patients of either gender from 9 districts of Karnataka and one patient each from Andhra Pradesh and Kerala, India were enrolled in the study. With a predefined severity criterion, 132 patients were segregated to the severe group. Multi organ involvement was seen in 59 (44.69%) patients. Phylogenetic analysis revealed JG-v like (48.97%), Karp-like (26.53%), JG-like (22.44%), and Kato-like (2.04%) strains in Karnataka. Patients infected with Orientia tsutsugamushi Karp-like strains had respiratory involvement (69.2%), cardiovascular involvement (46.2%) and thrombocytopenia (23.1%) and required higher hospital resource utilization.

Original languageEnglish
Article numbere0289126
Pages (from-to)e0289126
JournalPLoS One
Volume18
Issue number7 July
DOIs
Publication statusPublished - 07-2023

All Science Journal Classification (ASJC) codes

  • General

Fingerprint

Dive into the research topics of 'Clinical, laboratory, and molecular epidemiology of Orientia tsutsugamushi infection from Southwestern India'. Together they form a unique fingerprint.

Cite this