TY - JOUR
T1 - Clinico-pathological peculiarities of human papilloma virus driven head and neck squamous cell carcinoma
T2 - A comprehensive update
AU - Devaraja, K.
AU - Aggarwal, Sadhna
AU - Verma, Sumit Singh
AU - Gupta, Subash Chandra
PY - 2020/3/15
Y1 - 2020/3/15
N2 - Aims: The current article provides a detailed account of the current understanding of molecular and clinico-pathological aspects of Human papilloma virus (HPV) driven head and neck squamous cell carcinoma (HNSCC). Materials and methods: The literature review included most of the landmark trials and clinical studies related to the HPV driven HNSCC. Key findings: HPV positive HNSCC differ distinctly from HPV negative tobacco-related HNSCC, especially in oropharyngeal region. Therefore, the American joint committee on cancer`s latest manual for classification and staging of cancer suggests a separate staging system for HPV positive oropharyngeal cancers. Despite the younger patients being affected and the high propensity for cervical metastasis, the HPV positive oropharyngeal cancers respond much better to the treatment. The association with wild type TP53 and low EGFR expression confers the favorable prognosis in HPV driven HNSCC. Since the association is not universal, we suggest checking for p53 and EGFR expression status before considering de-intensification of therapy. In addition, the presence of matted lymph nodes and five or more nodes could mean relatively poorer prognosis, and are not suitable for de-intensification of therapy. The same is also true probably with higher T stage and co-existing tobacco use. The methods for the detection of p16, HPV DNA, HPV E6/E7 mRNA, anti-E6/E7 antibodies, in tissue, in serum and in saliva of patients, along with their clinical implications are also discussed. Significance: This article provides latest developments on the HPV driven HNSCC. ‘Diagnosis of transcriptionally active HPV infection,’ ‘Modalities for surveillance,’ ‘Implication of de-escalation of therapy’ are some of the critical issues that could serve the medical, the research as well as the patient communities.
AB - Aims: The current article provides a detailed account of the current understanding of molecular and clinico-pathological aspects of Human papilloma virus (HPV) driven head and neck squamous cell carcinoma (HNSCC). Materials and methods: The literature review included most of the landmark trials and clinical studies related to the HPV driven HNSCC. Key findings: HPV positive HNSCC differ distinctly from HPV negative tobacco-related HNSCC, especially in oropharyngeal region. Therefore, the American joint committee on cancer`s latest manual for classification and staging of cancer suggests a separate staging system for HPV positive oropharyngeal cancers. Despite the younger patients being affected and the high propensity for cervical metastasis, the HPV positive oropharyngeal cancers respond much better to the treatment. The association with wild type TP53 and low EGFR expression confers the favorable prognosis in HPV driven HNSCC. Since the association is not universal, we suggest checking for p53 and EGFR expression status before considering de-intensification of therapy. In addition, the presence of matted lymph nodes and five or more nodes could mean relatively poorer prognosis, and are not suitable for de-intensification of therapy. The same is also true probably with higher T stage and co-existing tobacco use. The methods for the detection of p16, HPV DNA, HPV E6/E7 mRNA, anti-E6/E7 antibodies, in tissue, in serum and in saliva of patients, along with their clinical implications are also discussed. Significance: This article provides latest developments on the HPV driven HNSCC. ‘Diagnosis of transcriptionally active HPV infection,’ ‘Modalities for surveillance,’ ‘Implication of de-escalation of therapy’ are some of the critical issues that could serve the medical, the research as well as the patient communities.
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U2 - 10.1016/j.lfs.2020.117383
DO - 10.1016/j.lfs.2020.117383
M3 - Review article
C2 - 32007572
AN - SCOPUS:85078897361
SN - 0024-3205
VL - 245
JO - Life Sciences
JF - Life Sciences
M1 - 117383
ER -