TY - JOUR
T1 - Cluster miRNAs and cancer
T2 - Diagnostic, prognostic and therapeutic opportunities
AU - Kabekkodu, Shama Prasada
AU - Shukla, Vaibhav
AU - Varghese, Vinay Koshy
AU - Adiga, Divya
AU - Vethil Jishnu, Padacherri
AU - Chakrabarty, Sanjiban
AU - Satyamoorthy, Kapaettu
N1 - Funding Information:
information Department of Biotechnology, Ministry of Science and Technology, Grant/Award Number: BT/PR2423/AGR/36/700/2011; Science and Engineering Research Board, Grant/Award Number: EMR/2016/002314We thank (a) Science and Engineering Research Board, Department of Science and Technology (DST), Government of India (Grant No: EMR/2016/002314), (b) Department of Biotechnology (DBT), Government of India (BT/PR2423/AGR/36/700/2011) and Dr. TMA Pai foundation Endowment award, Manipal Academy of Higher Education, Manipal for financial support. Structured Ph.D. fellowship from Manipal Academy of Higher Education and Senior Research Fellowship from Indian Council of Medical Research, Government of India are gratefully acknowledged.
Publisher Copyright:
© 2019 Wiley Periodicals, Inc.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - MiRNAs are class of noncoding RNA important for gene expression regulation in many plants, animals and viruses. MiRNA clusters contain a set of two or more miRNA encoding genes, transcribed together as polycistronic miRNAs. Currently, there are approximately 159 miRNA clusters reported in the human genome consisting of miRNAs ranging from two or more miRNA genes. A large proportion of clustered miRNAs resides in and around the fragile sites or cancer associated genomic hotspots and plays an important role in carcinogenesis. Altered expression of miRNA cluster can be pro-tumorigenic or anti-tumorigenic and can be targeted for clinical management of cancer. Over the past few years, manipulation of miRNA clusters expression is attempted for experimental purpose as well as for diagnostic, prognostic and therapeutic applications in cancer. Re-expression of miRNAs by epigenetic therapy, genome editing such as clustered regulatory interspaced short palindromic repeats (CRISPR) and miRNA mowers showed promising results in cancer therapy. In this review, we focused on the potential of miRNA clusters as a biomarker for diagnosis, prognosis, targeted therapy as well as strategies for modulating their expression in a therapeutic context. This article is categorized under: Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs RNA Processing > Processing of Small RNAs RNA in Disease and Development > RNA in Disease Regulatory RNAs/RNAi/Riboswitches > Biogenesis of Effector Small RNAs.
AB - MiRNAs are class of noncoding RNA important for gene expression regulation in many plants, animals and viruses. MiRNA clusters contain a set of two or more miRNA encoding genes, transcribed together as polycistronic miRNAs. Currently, there are approximately 159 miRNA clusters reported in the human genome consisting of miRNAs ranging from two or more miRNA genes. A large proportion of clustered miRNAs resides in and around the fragile sites or cancer associated genomic hotspots and plays an important role in carcinogenesis. Altered expression of miRNA cluster can be pro-tumorigenic or anti-tumorigenic and can be targeted for clinical management of cancer. Over the past few years, manipulation of miRNA clusters expression is attempted for experimental purpose as well as for diagnostic, prognostic and therapeutic applications in cancer. Re-expression of miRNAs by epigenetic therapy, genome editing such as clustered regulatory interspaced short palindromic repeats (CRISPR) and miRNA mowers showed promising results in cancer therapy. In this review, we focused on the potential of miRNA clusters as a biomarker for diagnosis, prognosis, targeted therapy as well as strategies for modulating their expression in a therapeutic context. This article is categorized under: Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs RNA Processing > Processing of Small RNAs RNA in Disease and Development > RNA in Disease Regulatory RNAs/RNAi/Riboswitches > Biogenesis of Effector Small RNAs.
UR - http://www.scopus.com/inward/record.url?scp=85070905399&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85070905399&partnerID=8YFLogxK
U2 - 10.1002/wrna.1563
DO - 10.1002/wrna.1563
M3 - Review article
AN - SCOPUS:85070905399
SN - 1757-7004
VL - 11
JO - Wiley interdisciplinary reviews. RNA
JF - Wiley interdisciplinary reviews. RNA
IS - 2
M1 - e1563
ER -