TY - JOUR
T1 - Coalescing aptamers and liquid-crystals for sensing applications
AU - Kulabhusan, Prabir Kumar
AU - Ray, Rohitraj
AU - Ramachandra, Suma G.
AU - Srinivasulu, Maddasani
AU - Hariharan, Arumugam
AU - Balaji, Krishnasamy
AU - Mani, Naresh Kumar
N1 - Funding Information:
We extend our special thanks to Department of Biotechnology and Department of Chemistry, Manipal Institute of Technology. We also acknowledge the help of Ms. Anusha Prabhu for assisting us during figure preparation. NKM specially thanks Dr. Praveen Kumar, Dr. Vijendra Prabhu and Dr. Peralam Prakash, Department of Microbiology, Kasturba Medical College Manipal for proof reading the manuscript. NKM acknowledges the initial financial support from Vision Group on Science and Technology, Government of Karnataka under RGS/F Scheme [Sanction Letter no.: KSTePS/ VGSTRGS/F/GRD No.711/2017–18]. Authors A.H & K.B thank PSG Institute of Technology and Applied Research for support and encouragement.
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/12
Y1 - 2022/12
N2 - A remarkable future of analytical science is being predicted by the growing importance of new sensing technologies, one being the liquid crystals-based sensing coupled with aptamer technology that has already started to materialize in the recent years. This paper aims to summarize the major studies that have been conducted and developments including sensitivity, selectivity and limit of detection (LOD). The research studies that we have reviewed here have been implemented for the efficient, rapid and label-free detection of three targets of interest, namely antibiotics such as kanamycin, tetracycline, sulphadimethoxine, biological markers such as platelet-derived growth factor-BB (PDGF-BB), interferon-gamma (IFN-Y) and pulmonary surfactant protein-A(SP-A) and finally heavy metals, certain fungal and bacterial toxins as well as hazardous chemicals like bisphenol A, malathion and cocaine, to name a few. We have introduced the basics principles of aptamers and liquid crystals (LCs), and their interaction with any target analyte. We have also put forth the current challenges and future opportunities pertaining to this field which indicate that sufficient advancements are yet to be seen in this promising domain of research.
AB - A remarkable future of analytical science is being predicted by the growing importance of new sensing technologies, one being the liquid crystals-based sensing coupled with aptamer technology that has already started to materialize in the recent years. This paper aims to summarize the major studies that have been conducted and developments including sensitivity, selectivity and limit of detection (LOD). The research studies that we have reviewed here have been implemented for the efficient, rapid and label-free detection of three targets of interest, namely antibiotics such as kanamycin, tetracycline, sulphadimethoxine, biological markers such as platelet-derived growth factor-BB (PDGF-BB), interferon-gamma (IFN-Y) and pulmonary surfactant protein-A(SP-A) and finally heavy metals, certain fungal and bacterial toxins as well as hazardous chemicals like bisphenol A, malathion and cocaine, to name a few. We have introduced the basics principles of aptamers and liquid crystals (LCs), and their interaction with any target analyte. We have also put forth the current challenges and future opportunities pertaining to this field which indicate that sufficient advancements are yet to be seen in this promising domain of research.
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U2 - 10.1016/j.microc.2022.107980
DO - 10.1016/j.microc.2022.107980
M3 - Review article
AN - SCOPUS:85138342464
SN - 0026-265X
VL - 183
JO - Microchemical Journal
JF - Microchemical Journal
M1 - 107980
ER -