Cognitive enhancement and neuroprotective effects of ancient ayurvedic medicinal plant celastrus paniculatus: An overview

Celastrus paniculatus, commonly known as Malkangani and Jyothishmati. Which is a traditional medicinal plant used in Ayurveda used for various purposes as a memory enhancer, analgesic, antiepileptic agent, antiinflammatory and sedative. The seed extracts are extensively investigated for various neuropharmacological actions and other reports are available confirming that the plant and their extract have nontropic action. It is also evaluated for the analgesic, anti-inflammatory, and anticonvulsantaction. The drug is also included in many formulations as one of the content which is available in market used for memory related problems. Alzheimer’s disease is a most common type of dementia characterized by progressive neuronal degeneration. Enhancement of the duration of life in human beings especially in developing as well as developed countries have resulted in increment in the patients number with dementia proportionally. Alzheimer’s disease (AD) is considered to be one of the main death cause in aged and elderly people. Therefore, the present paper is a complete review of the various pharmacological effects especially Alzhiemers disease of Celastrus paniculatus.