Collagen nanoparticles in drug delivery systems and tissue engineering

Ashni Arun; Pratyusha Malrautu; Anindita Laha; Hongrong Luo; Seeram Ramakrishna

doi:10.3390/app112311369

Collagen nanoparticles in drug delivery systems and tissue engineering

Ashni Arun, Pratyusha Malrautu, Anindita Laha, Hongrong Luo, Seeram Ramakrishna

Department of Chemical Engineering, Manipal Institute of Technology, Manipal

Research output: Contribution to journal › Review article › peer-review

19 Citations (Scopus)

Abstract

The versatile natural polymer, collagen, has gained vast attention in biomedicine. Due to its biocompatibility, biodegradability, weak antigenicity, biomimetics and well-known safety profile, it is widely used as a drug, protein and gene carrier, and as a scaffold matrix in tissue engineering. Nanoparticles develop favorable chemical and physical properties such as increased drug half-life, improved hydrophobic drug solubility and controlled and targeted drug release. Their reduced toxicity, controllable characteristics of scaffolds and stimuli-responsive behavior make them suitable in regenerative medicine and tissue engineering. Collagen associates and absorbs nanoparticles leading to significant impacts on their biological functioning in any biofluid. This review will discuss collagen nanoparticle preparation methods and their applications and developments in drug delivery systems and tissue engineering.

Original language	English
Article number	11369
Journal	Applied Sciences (Switzerland)
Volume	11
Issue number	23
DOIs	https://doi.org/10.3390/app112311369
Publication status	Published - 01-12-2021

All Science Journal Classification (ASJC) codes

Materials Science(all)
Instrumentation
Engineering(all)
Process Chemistry and Technology
Computer Science Applications
Fluid Flow and Transfer Processes

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abstract = "The versatile natural polymer, collagen, has gained vast attention in biomedicine. Due to its biocompatibility, biodegradability, weak antigenicity, biomimetics and well-known safety profile, it is widely used as a drug, protein and gene carrier, and as a scaffold matrix in tissue engineering. Nanoparticles develop favorable chemical and physical properties such as increased drug half-life, improved hydrophobic drug solubility and controlled and targeted drug release. Their reduced toxicity, controllable characteristics of scaffolds and stimuli-responsive behavior make them suitable in regenerative medicine and tissue engineering. Collagen associates and absorbs nanoparticles leading to significant impacts on their biological functioning in any biofluid. This review will discuss collagen nanoparticle preparation methods and their applications and developments in drug delivery systems and tissue engineering.",

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AU - Arun, Ashni

AU - Malrautu, Pratyusha

AU - Laha, Anindita

AU - Luo, Hongrong

AU - Ramakrishna, Seeram

PY - 2021/12/1

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AB - The versatile natural polymer, collagen, has gained vast attention in biomedicine. Due to its biocompatibility, biodegradability, weak antigenicity, biomimetics and well-known safety profile, it is widely used as a drug, protein and gene carrier, and as a scaffold matrix in tissue engineering. Nanoparticles develop favorable chemical and physical properties such as increased drug half-life, improved hydrophobic drug solubility and controlled and targeted drug release. Their reduced toxicity, controllable characteristics of scaffolds and stimuli-responsive behavior make them suitable in regenerative medicine and tissue engineering. Collagen associates and absorbs nanoparticles leading to significant impacts on their biological functioning in any biofluid. This review will discuss collagen nanoparticle preparation methods and their applications and developments in drug delivery systems and tissue engineering.

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Collagen nanoparticles in drug delivery systems and tissue engineering

Abstract

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