Collagen nanoparticles in drug delivery systems and tissue engineering

Ashni Arun; Pratyusha Malrautu; Anindita Laha; Hongrong Luo; Seeram Ramakrishna

doi:10.3390/app112311369

Collagen nanoparticles in drug delivery systems and tissue engineering

Ashni Arun
, Pratyusha Malrautu
, Anindita Laha^*
, Hongrong Luo
, Seeram Ramakrishna

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

96 Citations (Scopus)

Abstract

The versatile natural polymer, collagen, has gained vast attention in biomedicine. Due to its biocompatibility, biodegradability, weak antigenicity, biomimetics and well-known safety profile, it is widely used as a drug, protein and gene carrier, and as a scaffold matrix in tissue engineering. Nanoparticles develop favorable chemical and physical properties such as increased drug half-life, improved hydrophobic drug solubility and controlled and targeted drug release. Their reduced toxicity, controllable characteristics of scaffolds and stimuli-responsive behavior make them suitable in regenerative medicine and tissue engineering. Collagen associates and absorbs nanoparticles leading to significant impacts on their biological functioning in any biofluid. This review will discuss collagen nanoparticle preparation methods and their applications and developments in drug delivery systems and tissue engineering.

Original language	English
Article number	11369
Journal	Applied Sciences (Switzerland)
Volume	11
Issue number	23
DOIs	https://doi.org/10.3390/app112311369
Publication status	Published - 01-12-2021

All Science Journal Classification (ASJC) codes

General Materials Science
Instrumentation
General Engineering
Process Chemistry and Technology
Computer Science Applications
Fluid Flow and Transfer Processes

Access to Document

10.3390/app112311369

Cite this

@article{ab19cf80f63b44b5b6da2969dcc12dac,

title = "Collagen nanoparticles in drug delivery systems and tissue engineering",

abstract = "The versatile natural polymer, collagen, has gained vast attention in biomedicine. Due to its biocompatibility, biodegradability, weak antigenicity, biomimetics and well-known safety profile, it is widely used as a drug, protein and gene carrier, and as a scaffold matrix in tissue engineering. Nanoparticles develop favorable chemical and physical properties such as increased drug half-life, improved hydrophobic drug solubility and controlled and targeted drug release. Their reduced toxicity, controllable characteristics of scaffolds and stimuli-responsive behavior make them suitable in regenerative medicine and tissue engineering. Collagen associates and absorbs nanoparticles leading to significant impacts on their biological functioning in any biofluid. This review will discuss collagen nanoparticle preparation methods and their applications and developments in drug delivery systems and tissue engineering.",

author = "Ashni Arun and Pratyusha Malrautu and Anindita Laha and Hongrong Luo and Seeram Ramakrishna",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = dec,

day = "1",

doi = "10.3390/app112311369",

language = "English",

volume = "11",

journal = "Applied Sciences (Switzerland)",

issn = "2076-3417",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "23",

}

TY - JOUR

T1 - Collagen nanoparticles in drug delivery systems and tissue engineering

AU - Arun, Ashni

AU - Malrautu, Pratyusha

AU - Laha, Anindita

AU - Luo, Hongrong

AU - Ramakrishna, Seeram

PY - 2021/12/1

Y1 - 2021/12/1

N2 - The versatile natural polymer, collagen, has gained vast attention in biomedicine. Due to its biocompatibility, biodegradability, weak antigenicity, biomimetics and well-known safety profile, it is widely used as a drug, protein and gene carrier, and as a scaffold matrix in tissue engineering. Nanoparticles develop favorable chemical and physical properties such as increased drug half-life, improved hydrophobic drug solubility and controlled and targeted drug release. Their reduced toxicity, controllable characteristics of scaffolds and stimuli-responsive behavior make them suitable in regenerative medicine and tissue engineering. Collagen associates and absorbs nanoparticles leading to significant impacts on their biological functioning in any biofluid. This review will discuss collagen nanoparticle preparation methods and their applications and developments in drug delivery systems and tissue engineering.

AB - The versatile natural polymer, collagen, has gained vast attention in biomedicine. Due to its biocompatibility, biodegradability, weak antigenicity, biomimetics and well-known safety profile, it is widely used as a drug, protein and gene carrier, and as a scaffold matrix in tissue engineering. Nanoparticles develop favorable chemical and physical properties such as increased drug half-life, improved hydrophobic drug solubility and controlled and targeted drug release. Their reduced toxicity, controllable characteristics of scaffolds and stimuli-responsive behavior make them suitable in regenerative medicine and tissue engineering. Collagen associates and absorbs nanoparticles leading to significant impacts on their biological functioning in any biofluid. This review will discuss collagen nanoparticle preparation methods and their applications and developments in drug delivery systems and tissue engineering.

UR - https://www.scopus.com/pages/publications/85120550954

UR - https://www.scopus.com/pages/publications/85120550954#tab=citedBy

U2 - 10.3390/app112311369

DO - 10.3390/app112311369

M3 - Review article

AN - SCOPUS:85120550954

SN - 2076-3417

VL - 11

JO - Applied Sciences (Switzerland)

JF - Applied Sciences (Switzerland)

IS - 23

M1 - 11369

ER -

Collagen nanoparticles in drug delivery systems and tissue engineering

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this