TY - JOUR
T1 - Comparative role of SOX10 gene in the gliogenesis of central, peripheral, and enteric nervous systems
AU - Bhattarai, Chacchu
AU - Poudel, Phanindra P.
AU - Ghosh, Arnab
AU - Kalthur, Sneha G.
N1 - Funding Information:
We acknowledge Dr. Sharath Kumar Rao, Dr. DC Agarwal, Dr. BM Nagpal, Dr. BS Satish Rao, Dr. Vasudha Devi, Dr. Shyamala Hande, Dr. Guruprasad Kalthur, Dr. Prasanna LC, Dr. Niranjan Nayak, Dr. Kanaklata Iyer, Dr. Surjit Singh and Dr. BP Powar for their constant support to complete this study.
Publisher Copyright:
© 2022 International Society of Differentiation
PY - 2022/11/1
Y1 - 2022/11/1
N2 - SOX10 gene and SOX10 protein are responsible for the gliogenesis of neuroglia from the neural crest cells. Expression of SOX10 gene encodes SOX10 protein which binds with DNA at its minor groove via its HMG domain upon activation. SOX10 protein undergoes bending and changes its conformation after binding with DNA. Via its transactivation domain and HMG domain, it further activates several other transcription factors, these cause gliogenesis of the neural crest cells into neuroglia. In literature, it is stated that the SOX10 gene helps in the formation of schwann cells, oligodendrocytes, and enteric ganglia from neural crest cells. Altered expression of the SOX10 gene results in agliogenesis, dysmyelination, and demyelination in the nervous system as well as intestinal aganglionosis. This review highlighted that there is a role of the SOX10 gene and SOX10 protein in enteric gliogenesis from the neural crest cells.
AB - SOX10 gene and SOX10 protein are responsible for the gliogenesis of neuroglia from the neural crest cells. Expression of SOX10 gene encodes SOX10 protein which binds with DNA at its minor groove via its HMG domain upon activation. SOX10 protein undergoes bending and changes its conformation after binding with DNA. Via its transactivation domain and HMG domain, it further activates several other transcription factors, these cause gliogenesis of the neural crest cells into neuroglia. In literature, it is stated that the SOX10 gene helps in the formation of schwann cells, oligodendrocytes, and enteric ganglia from neural crest cells. Altered expression of the SOX10 gene results in agliogenesis, dysmyelination, and demyelination in the nervous system as well as intestinal aganglionosis. This review highlighted that there is a role of the SOX10 gene and SOX10 protein in enteric gliogenesis from the neural crest cells.
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U2 - 10.1016/j.diff.2022.09.001
DO - 10.1016/j.diff.2022.09.001
M3 - Review article
AN - SCOPUS:85139297203
SN - 0301-4681
VL - 128
SP - 13
EP - 25
JO - Differentiation
JF - Differentiation
ER -
