TY - JOUR
T1 - Comparative study of bone mineral density using quantitative computed tomography to establish a local population reference standard and comparison with existing osteoporosis Standards
T2 - Insights from south India
AU - Deevi, Hemanth Kumar
AU - B, Sanjay Kini
AU - A, Manjula
AU - Koteshwara, Prakashini
N1 - Publisher Copyright:
© 2025 The Authors
PY - 2025/7/1
Y1 - 2025/7/1
N2 - Background: Early identification of reduced bone mineral density (BMD) and providing appropriate measures depending on BMD values, lead to early prevention and treatment of osteoporosis-related complications effectively. Quantification of osteoporosis can also be done by quantitative computed tomography (qCT). The present study was conducted to derive a reference standard BMD using phantomless qCT software for our local population of South India. Methods: A hospital-based cross-sectional study was conducted among patients >20 years of age who were undergoing a CT study which included T12, L1 & L2 vertebrae and were free of obvious bone pathology. The axial CT series was used to calculate the BMD. Using the average BMD, we obtained from the patients in the age group of 20–39 years, an average and a standard deviation were calculated. Later we recalculated the T scores for patients across all age groups using cross-tabulations to identify how many people were under the osteoporosis group in each of the standards [US standards ie; the University of California, San Francisco (UCSF) standards, World Health Organization (WHO) standards and locally derived standards). Results: The mean BMD for the age group of 20–39 years were obtained for both males and females as 149.4 mg/cc2 and 152.5 mg/cc2 respectively. Based on the bone attenuation in CT we found that attenuation >120 Hounsfield units (HU) did not have any osteoporosis and attenuation >200 HU did not have any osteopenia according to our reference standards. Similarly, when we considered the values of UCSF standards we found that attenuation >180 HU did not have any osteoporosis and attenuation >240 HU did not have any osteopenia whereas according to WHO standards attenuation >130 HU did not have any osteoporosis and attenuation >210 HU did not have any osteopenia. Conclusion: Given the enormous patient volume of body CT scanning currently performed in older adults for a wide variety of clinical indications, this represents a unique opportunity to expand osteoporosis screening.
AB - Background: Early identification of reduced bone mineral density (BMD) and providing appropriate measures depending on BMD values, lead to early prevention and treatment of osteoporosis-related complications effectively. Quantification of osteoporosis can also be done by quantitative computed tomography (qCT). The present study was conducted to derive a reference standard BMD using phantomless qCT software for our local population of South India. Methods: A hospital-based cross-sectional study was conducted among patients >20 years of age who were undergoing a CT study which included T12, L1 & L2 vertebrae and were free of obvious bone pathology. The axial CT series was used to calculate the BMD. Using the average BMD, we obtained from the patients in the age group of 20–39 years, an average and a standard deviation were calculated. Later we recalculated the T scores for patients across all age groups using cross-tabulations to identify how many people were under the osteoporosis group in each of the standards [US standards ie; the University of California, San Francisco (UCSF) standards, World Health Organization (WHO) standards and locally derived standards). Results: The mean BMD for the age group of 20–39 years were obtained for both males and females as 149.4 mg/cc2 and 152.5 mg/cc2 respectively. Based on the bone attenuation in CT we found that attenuation >120 Hounsfield units (HU) did not have any osteoporosis and attenuation >200 HU did not have any osteopenia according to our reference standards. Similarly, when we considered the values of UCSF standards we found that attenuation >180 HU did not have any osteoporosis and attenuation >240 HU did not have any osteopenia whereas according to WHO standards attenuation >130 HU did not have any osteoporosis and attenuation >210 HU did not have any osteopenia. Conclusion: Given the enormous patient volume of body CT scanning currently performed in older adults for a wide variety of clinical indications, this represents a unique opportunity to expand osteoporosis screening.
UR - https://www.scopus.com/pages/publications/105004916517
UR - https://www.scopus.com/inward/citedby.url?scp=105004916517&partnerID=8YFLogxK
U2 - 10.1016/j.cegh.2025.102030
DO - 10.1016/j.cegh.2025.102030
M3 - Article
AN - SCOPUS:105004916517
SN - 2213-3984
VL - 34
JO - Clinical Epidemiology and Global Health
JF - Clinical Epidemiology and Global Health
M1 - 102030
ER -
