Comparison of anti-inflammatory efficacy of three different therapeutic modalities after mandibular third molar impaction surgery-a cross sectional study

To compare the efficacy of orally administered Prednisolone, Serratiopeptidase and Trypsinchymotrypsin in supressing inflammatory sequelae after third molar surgery. The study consisted of three groups of 15 patients who were prescribed oral medication of NSAID along with either Prednisolone, Serratiopeptidase or Trypsin-chymotrypsin. They were evaluated on the third and seventh postoperative days for pain, edema and inter-incisal opening. On the seventh postoperative day the serum C-Reactive Protein was also assessed. Resolution of pain, edema and mouth opening was best achieved by Prednisolone, followed by Trypsin-chymotrypsin and Serratiopedtidase. Similar results were obtained for serum C Reactive Protein values with Prednisolone and Trypsin-chymotrypsin giving closest to baseline values, while values remained slightly elevated with Serratiopeptidase. Prednisolone was the most effective antiinflammatory adjuvant to control inflammatory sequelae of third molar surgery followed by Trypsinchymotrypsin and then Serratiopetidase. Clinical Significance: Timely control of inflammatory sequelae with appropriate therapeutic modality results in faster functional rehabilitation.