TY - JOUR
T1 - Comparison of Chitosan-lactic Acid-poly vinyl alcohol and Chitosan-hydroxyapatite Composite Membrane as Wound Healing Accelerator
AU - Thakur, Goutam
AU - Pal, Kunal
AU - Pal, Subrata
AU - Chakraborty, Smritinath
AU - Anis, Arfat
N1 - Publisher Copyright:
© (2019) Society for Biomaterials & Artificial Organs.
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Wound healing is a complex biochemical process and may be promoted by moist wound dressings, which helps in maintaining a suitable micro-environment favorable for migration and proliferation of fibroblast cells. Chitosan has been used by many researchers to develop various wound healing products. The current study deals with the development of chitosan-poly (vinyl alcohol) blended membrane and chitosan-hydroxyapatite composite membrane. The membranes were prepared using lactic acid as solvent. The developed membranes were characterized for their mechanical strength hemocompatibility. Membranes demonstrated significantly different mechanical strength and hemocompatibilty. Further, preliminary results indicated that the developed membranes could be tried as wound dressing materials. The afore-mentioned membranes were used as wound dressing materials for the treatment of surgically induced wounds in matured Sprague-Dawley rats. The wound healing results indicated that the healing rate was faster with the chitosan-hydroxyapatite membrane.
AB - Wound healing is a complex biochemical process and may be promoted by moist wound dressings, which helps in maintaining a suitable micro-environment favorable for migration and proliferation of fibroblast cells. Chitosan has been used by many researchers to develop various wound healing products. The current study deals with the development of chitosan-poly (vinyl alcohol) blended membrane and chitosan-hydroxyapatite composite membrane. The membranes were prepared using lactic acid as solvent. The developed membranes were characterized for their mechanical strength hemocompatibility. Membranes demonstrated significantly different mechanical strength and hemocompatibilty. Further, preliminary results indicated that the developed membranes could be tried as wound dressing materials. The afore-mentioned membranes were used as wound dressing materials for the treatment of surgically induced wounds in matured Sprague-Dawley rats. The wound healing results indicated that the healing rate was faster with the chitosan-hydroxyapatite membrane.
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M3 - Article
AN - SCOPUS:85088897289
SN - 0971-1198
VL - 33
SP - 52
EP - 55
JO - Trends in Biomaterials and Artificial Organs
JF - Trends in Biomaterials and Artificial Organs
IS - 2
ER -