Computational Fluid Dynamics as a Simulation tool in the Formulation development of Parenteral and Biphasic Liquid Dosage Forms

Objectives: Parenteral preparations and biphasic liquid dosage forms are commonly available in the market to treat several disease conditions. Formulation and evaluation of these products include critical steps likemixing, filtration, filling, freeze drying and dissolution which areimportantto assure quality of the product. To understand these critical processes, computational fluid dynamics (CFD) can be applied as a simulation tool. Methods: The use of CFD in the formulation of parenteral formulations and biphasic liquids is described in this review. Discrete examples of how CFD is used in the formulation and evaluation of parenteral preparations and biphasic liquid dosage forms with an overview of different research works done in every unit operation using CFD will be discussed in this review. Conclusion: This review clearly explained the uses and application of CFD as a significant simulation tool in the formulation development of parenteral and biphasic liquid dosage forms.