Control of blood glucose concentration in type I diabetic patients

As the "artificial pancreas" becomes closer to reality, automated insulin delivery based on real-time glucose measurements becomes feasible for people with diabetes. This paper employs a new approach to regulate the blood glucose level of type I diabetic patient under an intensive insulin treatment. The closed-loop control scheme incorporates the design of robust H∞ controller to maintain the normoglycemic average of 80 mg/dl. Due to cost and complexity involved in testing the control algorithms to real patients, studies are done using a Type I diabetic patient model. Controller performance is assessed in terms of its ability to reject the effect of meal disturbance and to overcome the variability in the glucoseinsulin dynamics from patient to patient. Computer simulations are used to evaluate the effectiveness of the proposed technique and to show its superiority in controlling hyperglycemia over other existing algorithms.