TY - JOUR
T1 - Controlled Release Technologies for Chronotherapy
T2 - Current Status and Future Perspectives
AU - Bhat, Bhavana B.
AU - Mehta, Chetan H.
AU - Suresh, Akhil
AU - Velagacherla, Varalakshmi
AU - Nayak, Usha Y.
N1 - Funding Information:
The authors would like to express their sincere gratitude to Manipal Academy of Higher Education, Manipal, for providing facilities for the literature search and facilities to work in this area and for providing Dr. TMA Pai Fellowship to Akhil Suresh and Varalakshmi Velagacherla. Also, thanks to the Indian Council for Medical Research and the Government of India for providing a Senior Research Fellowship (Ref. No. 45/18/2020-Nan/BMS) to Mr. Chetan Hasmukh Mehta.
Publisher Copyright:
© 2023 Bentham Science Publishers.
PY - 2023
Y1 - 2023
N2 - The expression "as sure as night follows a day" emulates those certain cycles in the environment that are always stable. Circadian rhythms are a group of processes that occur within the body in synchronisation with the external factors in a 24 h cycle. Changes in lifestyle and work shifts have disrupted these stable rhythms, which is a leading cause of lifestyle diseases. Associations between these biological clocks and diseases are abundant. However, it is also known that certain drugs work more efficiently and have minimum toxicity when given during a particular phase of the circadian cycle. Chronotherapeutics focuses on treating diseases according to the endogenous processes which mediate xenobiotic metabolism and drug response at a cellular level. Therefore, treatment of those diseases that show aggravation of symptoms according to the circadian rhythms at a particular time is highly beneficial by chronotherapy. In this article, we have emphasised how the changes in rhythms caused diseases and how chronotherapeutic approaches such as controlled drug release technologies can be a better option for these circadian manipulations that seem to influence all types of disease conditions.
AB - The expression "as sure as night follows a day" emulates those certain cycles in the environment that are always stable. Circadian rhythms are a group of processes that occur within the body in synchronisation with the external factors in a 24 h cycle. Changes in lifestyle and work shifts have disrupted these stable rhythms, which is a leading cause of lifestyle diseases. Associations between these biological clocks and diseases are abundant. However, it is also known that certain drugs work more efficiently and have minimum toxicity when given during a particular phase of the circadian cycle. Chronotherapeutics focuses on treating diseases according to the endogenous processes which mediate xenobiotic metabolism and drug response at a cellular level. Therefore, treatment of those diseases that show aggravation of symptoms according to the circadian rhythms at a particular time is highly beneficial by chronotherapy. In this article, we have emphasised how the changes in rhythms caused diseases and how chronotherapeutic approaches such as controlled drug release technologies can be a better option for these circadian manipulations that seem to influence all types of disease conditions.
UR - https://www.scopus.com/pages/publications/85159757016
UR - https://www.scopus.com/pages/publications/85159757016#tab=citedBy
U2 - 10.2174/1381612829666230423144232
DO - 10.2174/1381612829666230423144232
M3 - Article
C2 - 37143271
AN - SCOPUS:85159757016
SN - 1381-6128
VL - 29
SP - 1069
EP - 1091
JO - Current Pharmaceutical Design
JF - Current Pharmaceutical Design
IS - 14
ER -