Convalescent Plasma Therapy Against Covid-19: A Comprehensive Review

Suchitra M Shenoy, Pooja Rao, Deepa Adiga S A, Nikhil Victor D'Souza, Basavaprabhu Achappa

Research output: Contribution to journalArticlepeer-review


The pandemic COVID-19, caused by Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2) continues to create havoc all over the world having caused
more than 40 million cases and more than 11,32.528 deaths worldwide as of October 21,
2020. The treatment of COVID-19 is proving to be a challenge to the medical fraternity
worldwide with no specific drug therapy or vaccine available in sight. The use of
Convalescent plasma (CP) therapy, a form of passive immunization, in the treatment of
COVID-19 has been gaining ground all over the world including India as convalescent plasma therapy has been used previously in virus infections like MERS-CoV, SARS-CoV, H1N1 and other viral infection with some success, when the situation was similar as in any infectious outbreak situations. This review looks at CP therapy as a possible treatment option for COVID-19 in terms of: type of antibodies in the convalescent plasma, mechanism of action, possible adverse effects, current approval status and its limitations in
the management of COVID-19.
Original languageEnglish
Pages (from-to)3374-3384
Number of pages11
JournalEuropean Journal of Molecular and Clinical Medicine
Issue number10
Publication statusPublished - 01-01-2020


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