TY - JOUR
T1 - Convenient access to 1,3,4-trisubstituted pyrazoles carrying 5-nitrothiophene moiety via 1,3-dipolar cycloaddition of sydnones with acetylenic ketones and their antimicrobial evaluation
AU - Satheesha Rai, N.
AU - Kalluraya, Balakrishna
AU - Lingappa, B.
AU - Shenoy, Shaliny
AU - Puranic, Vedavati G.
N1 - Funding Information:
The authors thank Head, RSIC, Chandigarh, and CDRI, Lucknow, for spectral and analytical data. The authors are also thankful to UGC New Delhi for the financial assistance through Major Research Project.
PY - 2008/8
Y1 - 2008/8
N2 - Novel 1-aryl-3-(5-nitro-2-thienyl)-4-aroyl-pyrazoles 7 have been synthesized by the 1,3-dipolar cycloaddition of 3-arylsydnones 3 with 1-aryl-3-(5-nitro-2-thienyl)-2-propyn-1-ones 6. The newly synthesized compounds were well characterized by elemental analysis, IR, 1H NMR and mass spectral studies. They were also screened for their antibacterial and antifungal activities against a variety of microorganisms and the results of such studies have been discussed in this article.
AB - Novel 1-aryl-3-(5-nitro-2-thienyl)-4-aroyl-pyrazoles 7 have been synthesized by the 1,3-dipolar cycloaddition of 3-arylsydnones 3 with 1-aryl-3-(5-nitro-2-thienyl)-2-propyn-1-ones 6. The newly synthesized compounds were well characterized by elemental analysis, IR, 1H NMR and mass spectral studies. They were also screened for their antibacterial and antifungal activities against a variety of microorganisms and the results of such studies have been discussed in this article.
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U2 - 10.1016/j.ejmech.2007.08.002
DO - 10.1016/j.ejmech.2007.08.002
M3 - Article
C2 - 17923171
AN - SCOPUS:48149103866
SN - 0223-5234
VL - 43
SP - 1715
EP - 1720
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
IS - 8
ER -