Correlation between serum ferritin and bone marrow iron stores

V. Anupama; Purnima S. Rao; Sushma Adappa; Prashantha Balanthimogru; Chakrapani Mahabala

doi:10.1177/0049475516678478

Correlation between serum ferritin and bone marrow iron stores

V. Anupama, Purnima S. Rao, Sushma Adappa, Prashantha Balanthimogru, Chakrapani Mahabala^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Bone marrow aspirate examination is a gold standard to assess bone marrow iron stores. The correlation between serum ferritin and bone marrow iron has not been established in detail, as the cutoff value for iron stores have not been uniformly established. Ours was a cross-sectional study. Perl’s Prussian blue stain was used to stain bone marrow, assessed by Gale’s grading. Receiver operating characteristic curve analysis and Spearman’s correlation coefficient calculated. Gale’s grading revealed iron store deficiency in 26 and sufficiency in 13. Spearman’s correlation coefficient of 0.90 showed a significant relation between serum ferritin and bone marrow iron stores. A serum ferritin of 228 pmol/L had high sensitivity and specificity for iron deficiency; our study suggests that this level be taken as the cutoff value to predict iron store deficiency in bone marrow.

Original language	English
Pages (from-to)	217-221
Number of pages	5
Journal	Tropical Doctor
Volume	47
Issue number	3
DOIs	https://doi.org/10.1177/0049475516678478
Publication status	Published - 01-07-2017

All Science Journal Classification (ASJC) codes

Public Health, Environmental and Occupational Health
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/0049475516678478

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abstract = "Bone marrow aspirate examination is a gold standard to assess bone marrow iron stores. The correlation between serum ferritin and bone marrow iron has not been established in detail, as the cutoff value for iron stores have not been uniformly established. Ours was a cross-sectional study. Perl{\textquoteright}s Prussian blue stain was used to stain bone marrow, assessed by Gale{\textquoteright}s grading. Receiver operating characteristic curve analysis and Spearman{\textquoteright}s correlation coefficient calculated. Gale{\textquoteright}s grading revealed iron store deficiency in 26 and sufficiency in 13. Spearman{\textquoteright}s correlation coefficient of 0.90 showed a significant relation between serum ferritin and bone marrow iron stores. A serum ferritin of 228 pmol/L had high sensitivity and specificity for iron deficiency; our study suggests that this level be taken as the cutoff value to predict iron store deficiency in bone marrow.",

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AU - Adappa, Sushma

AU - Balanthimogru, Prashantha

AU - Mahabala, Chakrapani

PY - 2017/7/1

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AB - Bone marrow aspirate examination is a gold standard to assess bone marrow iron stores. The correlation between serum ferritin and bone marrow iron has not been established in detail, as the cutoff value for iron stores have not been uniformly established. Ours was a cross-sectional study. Perl’s Prussian blue stain was used to stain bone marrow, assessed by Gale’s grading. Receiver operating characteristic curve analysis and Spearman’s correlation coefficient calculated. Gale’s grading revealed iron store deficiency in 26 and sufficiency in 13. Spearman’s correlation coefficient of 0.90 showed a significant relation between serum ferritin and bone marrow iron stores. A serum ferritin of 228 pmol/L had high sensitivity and specificity for iron deficiency; our study suggests that this level be taken as the cutoff value to predict iron store deficiency in bone marrow.

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Correlation between serum ferritin and bone marrow iron stores

Abstract

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