TY - JOUR
T1 - Cortico-hippocampal salvage in chronic aluminium induced neurodegeneration by Celastruspaniculatus seed oil
T2 - Neurobehavioural, biochemical, histological study
AU - Chakrabarty, Mrinmoy
AU - Bhat, Priyanka
AU - Kumari, Sweta
AU - D'Souza, Avin
AU - Bairy, K. L.
AU - Chaturvedi, Abhishek
AU - Natarajan, Archana
AU - Mohandas Rao, K. G.
AU - Kamath, Shobha
PY - 2012/4/1
Y1 - 2012/4/1
N2 - Objective: To investigate the effects of Celastruspaniculatus seed oil in preventing the onset of chronic aluminum induced cortico-hippocampal neurodegeneration and oxidative stress. Materials and Methods: An animal model of senile dementia of Alzheimer's type wasproduced by administering aluminum as aluminum chloride (4.2 mg/kg) intraperitoneally to male Wistar rats for 60days and results compared to untreated control. Neurobehavioral investigations of Morris water maze tests, passive avoidance test, rotarod test and biochemical estimations of acetylcholineterase, malondialdehyde, glucose-6-phosphate dehydrogenase, superoxide dismutase, and hemoglobin in blood were performed fortnightly which gauged the extent of global oxidative stress and progressive neural damage. Findings were fortified by the above enzyme assays and histology of brain at necropsy. Prophylactic oral C. paniculatus in two doses 0.5 ml and 1 ml, were given to animals and the results were analyzed in comparison to a similar rodent model with standard drug donepezil (0.5 mg/kg) intraperitoneally. Results: C. paniculatus showed a significant prevention in onset of aluminum induced neural insult and overall systemic oxidative stress which was corroborated by the enlisted neurobehavioral, biochemical, and histological evidence. Conclusion: C. paniculatus is a putative decelerator of Al-mediated Alzheimer's like pathobiology.
AB - Objective: To investigate the effects of Celastruspaniculatus seed oil in preventing the onset of chronic aluminum induced cortico-hippocampal neurodegeneration and oxidative stress. Materials and Methods: An animal model of senile dementia of Alzheimer's type wasproduced by administering aluminum as aluminum chloride (4.2 mg/kg) intraperitoneally to male Wistar rats for 60days and results compared to untreated control. Neurobehavioral investigations of Morris water maze tests, passive avoidance test, rotarod test and biochemical estimations of acetylcholineterase, malondialdehyde, glucose-6-phosphate dehydrogenase, superoxide dismutase, and hemoglobin in blood were performed fortnightly which gauged the extent of global oxidative stress and progressive neural damage. Findings were fortified by the above enzyme assays and histology of brain at necropsy. Prophylactic oral C. paniculatus in two doses 0.5 ml and 1 ml, were given to animals and the results were analyzed in comparison to a similar rodent model with standard drug donepezil (0.5 mg/kg) intraperitoneally. Results: C. paniculatus showed a significant prevention in onset of aluminum induced neural insult and overall systemic oxidative stress which was corroborated by the enlisted neurobehavioral, biochemical, and histological evidence. Conclusion: C. paniculatus is a putative decelerator of Al-mediated Alzheimer's like pathobiology.
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U2 - 10.4103/0976-500X.95520
DO - 10.4103/0976-500X.95520
M3 - Article
AN - SCOPUS:84878789170
SN - 0976-500X
VL - 3
SP - 161
EP - 171
JO - Journal of Pharmacology and Pharmacotherapeutics
JF - Journal of Pharmacology and Pharmacotherapeutics
IS - 2
ER -