Current pharmacotherapy options for conduct disorders in adolescents and children

Sohil Khan, John Down, Nisreen Aouira, William Bor, Alison Haywood, Robyn Littlewood, Helen Heussler, Brett McDermott

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)


Introduction: Conduct disorder (CD) is a common mental health disorder of childhood and adolescence. CD’s complexity, with its heterogenous clinical manifestations and overlapping comorbidities makes the application of evidence-based management approaches challenging. This article aims to combine a systematic review of the available literature, with a consensus opinion from both child and adolescent psychiatrists and developmental pediatricians on the clinical and pharmacological management of children and adolescents with conduct disorder (CD). Areas covered: The authors review the CD population and provide a systematic review and meta-analysis of the effectiveness and safety of pharmacotherapies using preferred reporting items for systematic review and meta-analysis (PRISMA) and strength of evidence recommendation taxonomy (SORT) guidelines. The authors then provide an expert clinical opinion for the use of different pharmacotherapies to address aggressive and disruptive behavior in children. Expert opinion: Atypical antipsychotics (e.g. risperidone) demonstrate evidence for efficacy in CD. Other pharmacotherapies (e.g. mood stabilizers, anticonvulsants, psychostimulants and selective norepinephrine reuptake inhibitors) have a low level of evidence for CD alone, however, can sometimes be effective in managing the symptoms of CD when other psychiatric disorders are also present.

Original languageEnglish
Pages (from-to)571-583
Number of pages13
JournalExpert Opinion on Pharmacotherapy
Issue number5
Publication statusPublished - 24-03-2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)


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