TY - JOUR
T1 - Current trends on resveratrol bioactivities to treat periodontitis
AU - Sharifi-Rad, Javad
AU - Quispe, Cristina
AU - Alfred, Mary Angelia
AU - Anil Kumar, Nanjangud Venaktesh
AU - Lombardi, Niccolò
AU - Cinquanta, Lucrezia
AU - Iriti, Marcello
AU - Varoni, Elena M.
AU - Gupta, Gaurav
AU - Chellappan, Dinesh Kumar
AU - Dua, Kamal
AU - Cardoso, Susana M.
AU - Peron, Gregorio
AU - Dey, Abhijit
AU - Cruz-Martins, Natália
AU - Rodrigues, Célia F.
N1 - Funding Information:
C.F.R. would like to acknowledge the UID/EQU/00511/2020 Project— Laboratory of Process Engineering, Environment, Biotechnology and Energy (LEPABE) , financed by national funds through FCT / MCTES (PIDDAC).
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/8
Y1 - 2021/8
N2 - Periodontitis is an inflammatory condition causing a severe infection in the gum, leading to tooth loss and related serious health hazards. Severe periodontitis is the sixth most prevalent medical condition, globally affecting about 743 million individuals. Resveratrol (3,5,4′-trihydroxystilbene) is a plant polyphenol, extensively popularized during the last decades owing to its promising beneficial effects on human health. A plethora of studies have been carried out and reviewed, retrieved from popular search engines to elucidate the complex bioactivity and the possible health benefits of resveratrol on periodontitis via numerous in vitro and in vivo studies. The underlying mode of action by which resveratrol exerts its health-promoting effects is still to be fully understood and, so far, they are ascribed to a multi-target action. Bioavailability, pharmacodynamics, pharmacokinetics, drug-drug interactions and possible toxicological considerations of resveratrol are also addressed. Resveratrol is indicated as a safe and an effective natural compound against periodontitis and can thus be an interesting alternative to treat this oral disease. Its antimicrobial activity is related to strong antioxidant and anti-inflammatory effects. More in-depth comprehensive studies are needed on human samples to elucidate the structure-activity relationship with bioactivity, for its successful implementation as a useful mainstream drug against periodontitis.
AB - Periodontitis is an inflammatory condition causing a severe infection in the gum, leading to tooth loss and related serious health hazards. Severe periodontitis is the sixth most prevalent medical condition, globally affecting about 743 million individuals. Resveratrol (3,5,4′-trihydroxystilbene) is a plant polyphenol, extensively popularized during the last decades owing to its promising beneficial effects on human health. A plethora of studies have been carried out and reviewed, retrieved from popular search engines to elucidate the complex bioactivity and the possible health benefits of resveratrol on periodontitis via numerous in vitro and in vivo studies. The underlying mode of action by which resveratrol exerts its health-promoting effects is still to be fully understood and, so far, they are ascribed to a multi-target action. Bioavailability, pharmacodynamics, pharmacokinetics, drug-drug interactions and possible toxicological considerations of resveratrol are also addressed. Resveratrol is indicated as a safe and an effective natural compound against periodontitis and can thus be an interesting alternative to treat this oral disease. Its antimicrobial activity is related to strong antioxidant and anti-inflammatory effects. More in-depth comprehensive studies are needed on human samples to elucidate the structure-activity relationship with bioactivity, for its successful implementation as a useful mainstream drug against periodontitis.
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U2 - 10.1016/j.fbio.2021.101205
DO - 10.1016/j.fbio.2021.101205
M3 - Review article
AN - SCOPUS:85109428146
SN - 2212-4292
VL - 42
JO - Food Bioscience
JF - Food Bioscience
M1 - 101205
ER -