Cytotoxic and anticancer activities of some 1-aryl-2-dimethylaminomethyl- 2-propen-1-one hydrochlorides

J. R. Dimmock; S. C. Vashishtha; S. A. Patil; N. Udupa; S. B. Dinesh; P. U. Devi; R. Kamath

Cytotoxic and anticancer activities of some 1-aryl-2-dimethylaminomethyl- 2-propen-1-one hydrochlorides

J. R. Dimmock^*
, S. C. Vashishtha
, S. A. Patil
, N. Udupa
, S. B. Dinesh
, P. U. Devi
, R. Kamath

^*Corresponding author for this work

Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

A series of 1-aryl-2-dimethylaminomethyl-2-propen-1-one hydrochlorides demonstrated marked cytotoxicity towards approximately 55 human tumour cell lines from different neoplastic diseases. In general they were more potent than melphalan and displayed selective toxicity towards human leukemic cells. A representative compound, 1-phenyl-2-dimethylaminomethyl-2-propen-1-one hydrochloride (2a), had similar cytotoxicity as melphalan towards murine P388 and L1210 leukemic cells. In addition, 2a reduced the sizes of a number of human tumour xenografts including colon, prostatic and melanotic cancers passaged in athymic mice. Compound 2a showed excellent activity towards Ehrlich ascites carcinoma and B₁₆F₁ melanoma in mice which was enhanced using niosomes. One may conclude from the data generated that 1-aryl-2- dimethylaminomethyl-2-propen-1-one hydrochlorides are a novel series of cytotoxic and anticancer agents.

Original language	English
Pages (from-to)	702-706
Number of pages	5
Journal	Pharmazie
Volume	53
Issue number	10
Publication status	Published - 1998

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Drug Discovery
Organic Chemistry
General Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science

Cite this

@article{a0053d25d9d64e939e0639288f2d65f0,

title = "Cytotoxic and anticancer activities of some 1-aryl-2-dimethylaminomethyl- 2-propen-1-one hydrochlorides",

abstract = "A series of 1-aryl-2-dimethylaminomethyl-2-propen-1-one hydrochlorides demonstrated marked cytotoxicity towards approximately 55 human tumour cell lines from different neoplastic diseases. In general they were more potent than melphalan and displayed selective toxicity towards human leukemic cells. A representative compound, 1-phenyl-2-dimethylaminomethyl-2-propen-1-one hydrochloride (2a), had similar cytotoxicity as melphalan towards murine P388 and L1210 leukemic cells. In addition, 2a reduced the sizes of a number of human tumour xenografts including colon, prostatic and melanotic cancers passaged in athymic mice. Compound 2a showed excellent activity towards Ehrlich ascites carcinoma and B16F1 melanoma in mice which was enhanced using niosomes. One may conclude from the data generated that 1-aryl-2- dimethylaminomethyl-2-propen-1-one hydrochlorides are a novel series of cytotoxic and anticancer agents.",

author = "Dimmock, \{J. R.\} and Vashishtha, \{S. C.\} and Patil, \{S. A.\} and N. Udupa and Dinesh, \{S. B.\} and Devi, \{P. U.\} and R. Kamath",

year = "1998",

language = "English",

volume = "53",

pages = "702--706",

journal = "Pharmazie",

issn = "0031-7144",

publisher = "Avoxa – Mediengruppe Deutscher Apotheker GmbH",

number = "10",

}

TY - JOUR

T1 - Cytotoxic and anticancer activities of some 1-aryl-2-dimethylaminomethyl- 2-propen-1-one hydrochlorides

AU - Dimmock, J. R.

AU - Vashishtha, S. C.

AU - Patil, S. A.

AU - Udupa, N.

AU - Dinesh, S. B.

AU - Devi, P. U.

AU - Kamath, R.

PY - 1998

Y1 - 1998

N2 - A series of 1-aryl-2-dimethylaminomethyl-2-propen-1-one hydrochlorides demonstrated marked cytotoxicity towards approximately 55 human tumour cell lines from different neoplastic diseases. In general they were more potent than melphalan and displayed selective toxicity towards human leukemic cells. A representative compound, 1-phenyl-2-dimethylaminomethyl-2-propen-1-one hydrochloride (2a), had similar cytotoxicity as melphalan towards murine P388 and L1210 leukemic cells. In addition, 2a reduced the sizes of a number of human tumour xenografts including colon, prostatic and melanotic cancers passaged in athymic mice. Compound 2a showed excellent activity towards Ehrlich ascites carcinoma and B16F1 melanoma in mice which was enhanced using niosomes. One may conclude from the data generated that 1-aryl-2- dimethylaminomethyl-2-propen-1-one hydrochlorides are a novel series of cytotoxic and anticancer agents.

AB - A series of 1-aryl-2-dimethylaminomethyl-2-propen-1-one hydrochlorides demonstrated marked cytotoxicity towards approximately 55 human tumour cell lines from different neoplastic diseases. In general they were more potent than melphalan and displayed selective toxicity towards human leukemic cells. A representative compound, 1-phenyl-2-dimethylaminomethyl-2-propen-1-one hydrochloride (2a), had similar cytotoxicity as melphalan towards murine P388 and L1210 leukemic cells. In addition, 2a reduced the sizes of a number of human tumour xenografts including colon, prostatic and melanotic cancers passaged in athymic mice. Compound 2a showed excellent activity towards Ehrlich ascites carcinoma and B16F1 melanoma in mice which was enhanced using niosomes. One may conclude from the data generated that 1-aryl-2- dimethylaminomethyl-2-propen-1-one hydrochlorides are a novel series of cytotoxic and anticancer agents.

UR - https://www.scopus.com/pages/publications/0031712071

UR - https://www.scopus.com/pages/publications/0031712071#tab=citedBy

M3 - Article

C2 - 9812337

AN - SCOPUS:0031712071

SN - 0031-7144

VL - 53

SP - 702

EP - 706

JO - Pharmazie

JF - Pharmazie

IS - 10

ER -

Cytotoxic and anticancer activities of some 1-aryl-2-dimethylaminomethyl- 2-propen-1-one hydrochlorides

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

Other files and links

Fingerprint

Cite this