TY - JOUR
T1 - Deciphering the role of MitomiRs in cancer
T2 - A comprehensive review
AU - Patel, Dimple
AU - Thankachan, Sanu
AU - Abu Fawaz, P. P.
AU - Venkatesh, Thejaswini
AU - Prasada Kabekkodu, Shama
AU - Suresh, Padmanaban S.
N1 - Funding Information:
PSS acknowledges the National Institute of Technology, Calicut, Kerala, India (Faculty research seed grant) and Department of Biotechnology (BT/PR16307/MED/30/1729/2016) Govt. of India for their support and encouragement. ST acknowledges the fellowship support from the Ministry of Education, Govt. of India, and the National Institute of Technology, Calicut.
Publisher Copyright:
© 2023 Elsevier B.V. and Mitochondria Research Society
PY - 2023/5
Y1 - 2023/5
N2 - MicroRNAs (miRNAs) are short non-coding RNAs that regulate many metabolic and signal transduction pathways. The role of miRNAs, usually found in the cytoplasm, in regulating gene expression and cancer progression has been extensively studied in the last few decades. However, very recently, miRNAs were found to localize in the mitochondria. MiRNAs that specifically localize in the mitochondria and the cytoplasmic miRNAs associated with mitochondria that directly or indirectly modulate specific mitochondrial functions are termed as “mitomiRs”. Although it is not clear about the origin of mitomiRs that are situated within mitochondria (nuclear or mitochondrial origin), it is evident that they have specific functions in modulating gene expression and regulating important mitochondrial metabolic pathways. Through this review, we aim to delineate the mechanisms by which mitomiRs alter mitochondrial metabolic pathways and influence the initiation and progression of cancer. We further discuss the functions of particular mitomiRs, which have been widely studied in the context of mitochondrial metabolism and oncogenic signaling pathways. Based on the current knowledge, we can conclude that mitomiRs contribute significantly to mitochondrial function and metabolic regulation, and that dysregulation of mitomiRs can aid the proliferation of cancer cells. Therefore, the less explored area of mitomiRs’ biology can be an important topic of research investigation in the future for targeting cancer cells.
AB - MicroRNAs (miRNAs) are short non-coding RNAs that regulate many metabolic and signal transduction pathways. The role of miRNAs, usually found in the cytoplasm, in regulating gene expression and cancer progression has been extensively studied in the last few decades. However, very recently, miRNAs were found to localize in the mitochondria. MiRNAs that specifically localize in the mitochondria and the cytoplasmic miRNAs associated with mitochondria that directly or indirectly modulate specific mitochondrial functions are termed as “mitomiRs”. Although it is not clear about the origin of mitomiRs that are situated within mitochondria (nuclear or mitochondrial origin), it is evident that they have specific functions in modulating gene expression and regulating important mitochondrial metabolic pathways. Through this review, we aim to delineate the mechanisms by which mitomiRs alter mitochondrial metabolic pathways and influence the initiation and progression of cancer. We further discuss the functions of particular mitomiRs, which have been widely studied in the context of mitochondrial metabolism and oncogenic signaling pathways. Based on the current knowledge, we can conclude that mitomiRs contribute significantly to mitochondrial function and metabolic regulation, and that dysregulation of mitomiRs can aid the proliferation of cancer cells. Therefore, the less explored area of mitomiRs’ biology can be an important topic of research investigation in the future for targeting cancer cells.
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U2 - 10.1016/j.mito.2023.04.004
DO - 10.1016/j.mito.2023.04.004
M3 - Review article
C2 - 37120081
AN - SCOPUS:85156205795
SN - 1567-7249
VL - 70
SP - 118
EP - 130
JO - Mitochondrion
JF - Mitochondrion
ER -
