TY - JOUR
T1 - Delayed Structure – function alterations in Pancreas and Liver of Rodent Diabetic Model treated with Salacia oblonga.
AU - Bhat, Bhagyajyothi M.
AU - Raghuveer, C. V.
AU - D’souza, Vivian
AU - Ilanthodi, Sandhya
AU - Manjrekar, Poornima A.
N1 - Funding Information:
The authors are thankful to the Indian Council of Medical Research (ICMR) for their monetary support for carrying out this project (Ad hoc research project No. 59/18/2005/BMS/TRM).
Publisher Copyright:
© RJPT All right reserved.
PY - 2023/2
Y1 - 2023/2
N2 - Salacia oblonga (S. oblonga) is a component of several antidiabetic medications in alternative and folklore medicine. An evaluation of the hydroalcoholic root extract of S.oblonga (SOE) on the hepatocellular and pancreatic environment in the diabetic (Streptozotocin) rodent model was designed. SOE was fed in two doses for a period of 16 weeks. Regeneration of endocrine pancreas, significant increase in hepatic and pancreatic Vitamin C, reduced Glutathione (GSH), Protein thiols (PT) and decrease in Malondialdehyde (MDA measured as TBARS) and Carbonyl proteins (CP) were observed on treatment with SOE. Conversely, there was also an increase in alkaline phosphatase (ALP) and gamma glutamyl transferase (GGT). Corroborating the above findings, histopathological examination of the liver and pancreatic tissue showed disrupted architecture in treated rats. It may be suggested that SOE has a sustained hepatic antioxidant effect and improved β-cell structure and function in diabetic rats, but the higher dose was mildly toxic to hepatocytes necessitating an exercise of caution in using SOE for therapy for prolonged periods.
AB - Salacia oblonga (S. oblonga) is a component of several antidiabetic medications in alternative and folklore medicine. An evaluation of the hydroalcoholic root extract of S.oblonga (SOE) on the hepatocellular and pancreatic environment in the diabetic (Streptozotocin) rodent model was designed. SOE was fed in two doses for a period of 16 weeks. Regeneration of endocrine pancreas, significant increase in hepatic and pancreatic Vitamin C, reduced Glutathione (GSH), Protein thiols (PT) and decrease in Malondialdehyde (MDA measured as TBARS) and Carbonyl proteins (CP) were observed on treatment with SOE. Conversely, there was also an increase in alkaline phosphatase (ALP) and gamma glutamyl transferase (GGT). Corroborating the above findings, histopathological examination of the liver and pancreatic tissue showed disrupted architecture in treated rats. It may be suggested that SOE has a sustained hepatic antioxidant effect and improved β-cell structure and function in diabetic rats, but the higher dose was mildly toxic to hepatocytes necessitating an exercise of caution in using SOE for therapy for prolonged periods.
UR - http://www.scopus.com/inward/record.url?scp=85162124104&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85162124104&partnerID=8YFLogxK
U2 - 10.52711/0974-360X.2023.00149
DO - 10.52711/0974-360X.2023.00149
M3 - Article
AN - SCOPUS:85162124104
SN - 0974-3618
VL - 16
SP - 879
EP - 884
JO - Research Journal of Pharmacy and Technology
JF - Research Journal of Pharmacy and Technology
IS - 2
ER -
