Demystifying the Potential of Polymeric Lipids as Substitute in Regenerative Applications: A Review

The objective of a regenerative medicine is to repair, restore, and regenerate tissues and organs that occurred due to injury or a defect or disease. Additionally, the purpose of regenerative medicine is to reverse the aging process of the body by utilizing the body's innate healing ability. There is still a significant venture that needs to be directed for advancement in the arena of regenerative medicine, which makes use of products derived from cell therapy as well as for biomedical. Stem cells and growth factors are the primary components of regenerative medicine; hence, novel drug delivering systems are now being studied to augment the transport of active pharmaceuticals. Lipid-based complexed with therapeutics is suited for site-specific and controlled drug release. Lipids are biocompatible and available from various sources in various molecular weights that self-assemble into various forms with hydrophilic and hydrophobic parts. By enhancing plasma membrane fluidity, excipients such non-ionic surfactants, fatty acids, and glycerides increase permeability. Liposomes, nanoparticles, nano-emulsions, and micelles are nano-lipid carriers that can improve bioavailability of both hydrophilic and lipophilic medicines. The lipoidal-polymeric carriers had emerged as promising drug delivering systems for a multifaceted application due to cytocompatibility, ecofriendly, and ability to encapsulate a variety of drugs. Further, utilizing cell treatment products as well as biomedical or tissue engineering, regenerative medicine is a rapidly developing discipline. Furthermore, similar vein, delivery technologies that are combined with stem cells promote engraftment, differentiation, and cell survival. Hence the colloidal Lipid-based carrier has impending as versatile drug delivering systems for multifaceted applications. Therefore, the objective is of the review is to offer an abridged information on the significance of Lipid-based regenerative medicine as delivering technology in the process of offering cells with a confined ecosystem that facilitates them to thrive and distinguish in an effective manner.