Deoxycholate amphotericin for histoplasmosis in a patient with poor kidney function

Gokul Krishnan; Nitin Gupta; Kavitha Saravu; Handattu Manjunath Hande; Ruchee Khanna

doi:10.1136/bcr-2021-243984

Deoxycholate amphotericin for histoplasmosis in a patient with poor kidney function

Research output: Contribution to journal › Article › peer-review

Abstract

A 48-year-old male patient living with HIV presented to our hospital with fever and weight loss. On evaluation, he was found to have pancytopenia, deranged liver and kidney function. CD4 count was 13 cells/uL. Bone marrow examination done because of pancytopenia showed yeast forms of histoplasmosis. Although liposomal amphotericin B is preferred for induction, he was treated with deoxycholate amphotericin B despite poor kidney function because of financial constraints. He was treated for 12 days with intravenous amphotericin, during which his clinical condition significantly improved. He was discharged on oral itraconazole.

Original language	English
Article number	e243984
Journal	BMJ Case Reports
Volume	14
Issue number	8
DOIs	https://doi.org/10.1136/bcr-2021-243984
Publication status	Published - 26-08-2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

General Medicine

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10.1136/bcr-2021-243984

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title = "Deoxycholate amphotericin for histoplasmosis in a patient with poor kidney function",

abstract = "A 48-year-old male patient living with HIV presented to our hospital with fever and weight loss. On evaluation, he was found to have pancytopenia, deranged liver and kidney function. CD4 count was 13 cells/uL. Bone marrow examination done because of pancytopenia showed yeast forms of histoplasmosis. Although liposomal amphotericin B is preferred for induction, he was treated with deoxycholate amphotericin B despite poor kidney function because of financial constraints. He was treated for 12 days with intravenous amphotericin, during which his clinical condition significantly improved. He was discharged on oral itraconazole.",

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AU - Krishnan, Gokul

AU - Gupta, Nitin

AU - Saravu, Kavitha

AU - Hande, Handattu Manjunath

AU - Khanna, Ruchee

N1 - Publisher Copyright: © BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2021/8/26

Y1 - 2021/8/26

N2 - A 48-year-old male patient living with HIV presented to our hospital with fever and weight loss. On evaluation, he was found to have pancytopenia, deranged liver and kidney function. CD4 count was 13 cells/uL. Bone marrow examination done because of pancytopenia showed yeast forms of histoplasmosis. Although liposomal amphotericin B is preferred for induction, he was treated with deoxycholate amphotericin B despite poor kidney function because of financial constraints. He was treated for 12 days with intravenous amphotericin, during which his clinical condition significantly improved. He was discharged on oral itraconazole.

AB - A 48-year-old male patient living with HIV presented to our hospital with fever and weight loss. On evaluation, he was found to have pancytopenia, deranged liver and kidney function. CD4 count was 13 cells/uL. Bone marrow examination done because of pancytopenia showed yeast forms of histoplasmosis. Although liposomal amphotericin B is preferred for induction, he was treated with deoxycholate amphotericin B despite poor kidney function because of financial constraints. He was treated for 12 days with intravenous amphotericin, during which his clinical condition significantly improved. He was discharged on oral itraconazole.

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Deoxycholate amphotericin for histoplasmosis in a patient with poor kidney function

Abstract

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