Depth detection limits of diffuse fluorescence tomography for system combination with US imaging guidance

  • Héctor A. García*
  • , Madhusudan B. Kulkarni
  • , Matthew S. Reed
  • , Xu Cao
  • , Marvin M. Doyley
  • , Brian W. Pogue
  • *Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We performed a depth discrimination study on a continuous-wave (CW) multichannel fluorescence tomography developed and intended to be part of a concurrent DFT-US imaging system. Different interoptode distances were used to sense the depth at which a fluorescing inclusion of ICG was located inside a liquid phantom optically mimicking living tissue. Additionally, the contrast between bulk and inclusion was adjusted by modifying the optical parameters between them. Results suggest that depth detection limits up to 30 mm could be reached with a sufficient signal-to-noise ratio, revealing the feasibility of the concept of US-guided fluorescence sensing as a surgical procedure.

Original languageEnglish
Title of host publicationMultimodal Biomedical Imaging XX
EditorsXavier Intes, Marien Ochoa, Mohammad Abbas Yaseen
PublisherSPIE
ISBN (Electronic)9781510683662
DOIs
Publication statusPublished - 2025
EventMultimodal Biomedical Imaging XX 2025 - San Francisco, United States
Duration: 25-01-202526-01-2025

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume13309
ISSN (Print)1605-7422

Conference

ConferenceMultimodal Biomedical Imaging XX 2025
Country/TerritoryUnited States
CitySan Francisco
Period25-01-2526-01-25

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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