TY - JOUR
T1 - Deregulated miRNA clusters in ovarian cancer
T2 - Imperative implications in personalized medicine
AU - Kandettu, Amoolya
AU - Adiga, Divya
AU - Devi, Vasudha
AU - Suresh, Padmanaban S.
AU - Chakrabarty, Sanjiban
AU - Radhakrishnan, Raghu
AU - Kabekkodu, Shama Prasada
N1 - Funding Information:
The study is supported by Science and Engineering Research Board , Department of Science and Technology , Government of India (No. EMR/2016/002314 ), Indian Council of Medical Research , Government of India (No. 2020-3173 ).
Funding Information:
We thank ICMR-senior research fellowship (Reference ID-2019/4115/CMB/BMS), Government of India, and Dr. TMA Pai structured Ph.D. fellowship, Manipal Academy of Higher Education (MAHE) for financial assistance. We acknowledge Centre for DNA repair and Genome Stability (CDRGS), MAHE, Manipal, Karnataka.
Funding Information:
The study is supported by Science and Engineering Research Board, Department of Science and Technology, Government of India (No. EMR/2016/002314), Indian Council of Medical Research, Government of India (No. 2020-3173).
Publisher Copyright:
© 2022 Chongqing Medical University
PY - 2022/11
Y1 - 2022/11
N2 - Ovarian cancer (OC) is one of the most common and fatal types of gynecological cancer. OC is usually detected at the advanced stages of the disease, making it highly lethal. miRNAs are single-stranded, small non-coding RNAs with an approximate size ranging around 22 nt. Interestingly, a considerable proportion of miRNAs are organized in clusters with miRNA genes placed adjacent to one another, getting transcribed together to result in miRNA clusters (MCs). MCs comprise two or more miRNAs that follow the same orientation during transcription. Abnormal expression of the miRNA cluster has been identified as one of the key drivers in OC. MC exists both as tumor-suppressive and oncogenic clusters and has a significant role in OC pathogenesis by facilitating cancer cells to acquire various hallmarks. The present review summarizes the regulation and biological function of MCs in OC. The review also highlights the utility of abnormally expressed MCs in the clinical management of OC.
AB - Ovarian cancer (OC) is one of the most common and fatal types of gynecological cancer. OC is usually detected at the advanced stages of the disease, making it highly lethal. miRNAs are single-stranded, small non-coding RNAs with an approximate size ranging around 22 nt. Interestingly, a considerable proportion of miRNAs are organized in clusters with miRNA genes placed adjacent to one another, getting transcribed together to result in miRNA clusters (MCs). MCs comprise two or more miRNAs that follow the same orientation during transcription. Abnormal expression of the miRNA cluster has been identified as one of the key drivers in OC. MC exists both as tumor-suppressive and oncogenic clusters and has a significant role in OC pathogenesis by facilitating cancer cells to acquire various hallmarks. The present review summarizes the regulation and biological function of MCs in OC. The review also highlights the utility of abnormally expressed MCs in the clinical management of OC.
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U2 - 10.1016/j.gendis.2021.12.026
DO - 10.1016/j.gendis.2021.12.026
M3 - Review article
AN - SCOPUS:85127320763
SN - 2352-3042
VL - 9
SP - 1443
EP - 1465
JO - Genes and Diseases
JF - Genes and Diseases
IS - 6
ER -