Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor β (TR-β) selective ligands

Saurin Raval; Preeti Raval; Debdutta Bandyopadhyay; Krunal Soni; Digambar Yevale; Digvijay Jogiya; Honey Modi; Amit Joharapurkar; Neha Gandhi; Mukul R. Jain; Pankaj R. Patel

doi:10.1016/j.bmcl.2008.06.038

Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor β (TR-β) selective ligands

Saurin Raval^*
, Preeti Raval
, Debdutta Bandyopadhyay
, Krunal Soni
, Digambar Yevale
, Digvijay Jogiya
, Honey Modi
, Amit Joharapurkar
, Neha Gandhi
, Mukul R. Jain
, Pankaj R. Patel

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Design and synthesis of a novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives are reported and their in vitro thyroid hormone receptor selectivity has been evaluated in the thyroid luciferase receptor assay. The 3-[3,5-dichloro-4-(4-hydroxy-3-isopropylphenoxy)-phenylamino]-4-hydroxy- cyclobut-3-ene-1,2-dione 21 has shown selectivity towards thyroid hormone receptor β.

Original language	English
Pages (from-to)	3919-3924
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	18
Issue number	14
DOIs	https://doi.org/10.1016/j.bmcl.2008.06.038
Publication status	Published - 15-07-2008

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2008.06.038

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Raval, S., Raval, P., Bandyopadhyay, D., Soni, K., Yevale, D., Jogiya, D., Modi, H., Joharapurkar, A., Gandhi, N., Jain, M. R., & Patel, P. R. (2008). Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor β (TR-β) selective ligands. Bioorganic and Medicinal Chemistry Letters, 18(14), 3919-3924. https://doi.org/10.1016/j.bmcl.2008.06.038

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abstract = "Design and synthesis of a novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives are reported and their in vitro thyroid hormone receptor selectivity has been evaluated in the thyroid luciferase receptor assay. The 3-[3,5-dichloro-4-(4-hydroxy-3-isopropylphenoxy)-phenylamino]-4-hydroxy- cyclobut-3-ene-1,2-dione 21 has shown selectivity towards thyroid hormone receptor β.",

author = "Saurin Raval and Preeti Raval and Debdutta Bandyopadhyay and Krunal Soni and Digambar Yevale and Digvijay Jogiya and Honey Modi and Amit Joharapurkar and Neha Gandhi and Jain, \{Mukul R.\} and Patel, \{Pankaj R.\}",

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Raval, S, Raval, P, Bandyopadhyay, D, Soni, K, Yevale, D, Jogiya, D, Modi, H, Joharapurkar, A, Gandhi, N, Jain, MR & Patel, PR 2008, 'Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor β (TR-β) selective ligands', Bioorganic and Medicinal Chemistry Letters, vol. 18, no. 14, pp. 3919-3924. https://doi.org/10.1016/j.bmcl.2008.06.038

TY - JOUR

T1 - Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor β (TR-β) selective ligands

AU - Raval, Saurin

AU - Raval, Preeti

AU - Bandyopadhyay, Debdutta

AU - Soni, Krunal

AU - Yevale, Digambar

AU - Jogiya, Digvijay

AU - Modi, Honey

AU - Joharapurkar, Amit

AU - Gandhi, Neha

AU - Jain, Mukul R.

AU - Patel, Pankaj R.

PY - 2008/7/15

Y1 - 2008/7/15

N2 - Design and synthesis of a novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives are reported and their in vitro thyroid hormone receptor selectivity has been evaluated in the thyroid luciferase receptor assay. The 3-[3,5-dichloro-4-(4-hydroxy-3-isopropylphenoxy)-phenylamino]-4-hydroxy- cyclobut-3-ene-1,2-dione 21 has shown selectivity towards thyroid hormone receptor β.

AB - Design and synthesis of a novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives are reported and their in vitro thyroid hormone receptor selectivity has been evaluated in the thyroid luciferase receptor assay. The 3-[3,5-dichloro-4-(4-hydroxy-3-isopropylphenoxy)-phenylamino]-4-hydroxy- cyclobut-3-ene-1,2-dione 21 has shown selectivity towards thyroid hormone receptor β.

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VL - 18

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EP - 3924

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 14

ER -

Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor β (TR-β) selective ligands

Abstract

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